Sophie Emond1, Francis Brunelle. 1. Department of Pediatric Radiology, Hôpital Necker Enfants Malades, Paris, France. sophieemondgonsard@yahoo.fr
Abstract
BACKGROUND: There is a paucity of evidence with regard to the safety of contrast medium administration at MRI in neonates and infants. PURPOSE: To assess immediate adverse reactions in children younger than 18 months of age during routine clinical utilization of gadoteric acid (Gd-DOTA) in a cohort of patients with nonselected indications. MATERIALS AND METHODS: One hundred and four neonates and infants were enrolled in a postmarketing survey with Gd-DOTA (Dotarem, Guerbet, Roissy, France) from a single pediatric hospital. A standardized questionnaire was used to collect the patient information. RESULTS: All included children, ages 3 days to 18 months, received one injection of Gd-DOTA (volume 0.6-4 ml). No immediate adverse event was reported. CONCLUSION: This postmarketing study involving neonates and infants suggests a favorable safety profile of Gd-DOTA in routine practice.
BACKGROUND: There is a paucity of evidence with regard to the safety of contrast medium administration at MRI in neonates and infants. PURPOSE: To assess immediate adverse reactions in children younger than 18 months of age during routine clinical utilization of gadoteric acid (Gd-DOTA) in a cohort of patients with nonselected indications. MATERIALS AND METHODS: One hundred and four neonates and infants were enrolled in a postmarketing survey with Gd-DOTA (Dotarem, Guerbet, Roissy, France) from a single pediatric hospital. A standardized questionnaire was used to collect the patient information. RESULTS: All included children, ages 3 days to 18 months, received one injection of Gd-DOTA (volume 0.6-4 ml). No immediate adverse event was reported. CONCLUSION: This postmarketing study involving neonates and infants suggests a favorable safety profile of Gd-DOTA in routine practice.
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