Literature DB >> 21783978

Genetic polymorphism of glutathione S-transferase M1 and T1 in Delhi population of Northern India.

Satyender Singh1, Vivek Kumar, Sachin Thakur, Basu Dev Banerjee, Shyam Sunder Grover, Devender Singh Rawat, Syed Tazeen Pasha, Sudhir Kumar Jain, Shiv Lal, Arvind Rai.   

Abstract

Glutathione S-transferases (GSTs), protect cells from reactive chemical intermediates and oxidative stress. Among different classes of GSTs, GSTM1 (Mu) and GSTT1 (theta) are found to be genetically deleted. Present study was intended to genotype homozygous null distribution of GSTM1 and GSTT1 in healthy individuals of Delhi, located in Northern India. Out of 309 healthy individuals included in this study, we have found genetic deletion in 21% and 27.4%, GSTM1 and GSTT1 genes, respectively. A small proportion (0.7%) population showed deletion of both the genes. The prevalence of the GSTM1(*)0/0 and GSTT1(*)0/0 genotypes varied within India compared to communities in Chinese, Japanese, Korean and Caucasian.
Copyright © 2009 Elsevier B.V. All rights reserved.

Entities:  

Year:  2009        PMID： 21783978     DOI： 10.1016/j.etap.2009.01.010

Source DB:  PubMed          Journal:  Environ Toxicol Pharmacol        ISSN： 1382-6689            Impact factor:   4.860


  6 in total

1.  Influence of glutathione S-transferase polymorphisms (GSTT1, GSTM1, GSTP1) on type-2 diabetes mellitus (T2D) risk in an endogamous population from north India.

Authors:  Sarabjit S Mastana; Antarpreet Kaur; Rachel Hale; Martin R Lindley
Journal:  Mol Biol Rep       Date:  2013-11-08       Impact factor: 2.316

2.  Technical reproducibility of single-nucleotide and size-based DNA biomarker assessment using DNA extracted from formalin-fixed, paraffin-embedded tissues.

Authors:  Shenli Zhang; Iain B Tan; Nur S Sapari; Heike I Grabsch; Alicia Okines; Elizabeth C Smyth; Toru Aoyama; Lindsay C Hewitt; Imran Inam; Dan Bottomley; Matthew Nankivell; Sally P Stenning; David Cunningham; Andrew Wotherspoon; Akira Tsuburaya; Takaki Yoshikawa; Richie Soong; Patrick Tan
Journal:  J Mol Diagn       Date:  2015-03-04       Impact factor: 5.568

3.  Glutathione S-transferase M1 and T1 null genotype frequency distribution among four tribal populations of western India.

Authors:  Prem Chandra Suthar; Pulakes Purkait; Kiran Uttaravalli; B N Sarkar; Rakshit Ameta; Mithun Sikdar
Journal:  J Genet       Date:  2018-03       Impact factor: 1.166

Review 4.  Distribution of genetic polymorphisms of genes encoding drug metabolizing enzymes & drug transporters - a review with Indian perspective.

Authors:  Gurusamy Umamaheswaran; Dhakchinamoorthi Krishna Kumar; Chandrasekaran Adithan
Journal:  Indian J Med Res       Date:  2014-01       Impact factor: 2.375

5.  Analyses of Genetic Variations of Glutathione S-Transferase Mu1 and Theta1 Genes in Bangladeshi Tannery Workers and Healthy Controls.

Authors:  Jobaida Akther; Akio Ebihara; Tsutomu Nakagawa; Laila N Islam; Fumiaki Suzuki; Md Ismail Hosen; Mahmud Hossain; A H M Nurun Nabi
Journal:  Biomed Res Int       Date:  2016-05-12       Impact factor: 3.411

6.  Polymorphism of Glutathione S-transferase Genes and the Risk of Toxic Liver Damage in Petrochemical Workers.

Authors:  Elvira Timeryanovna Valeeva; Guzel Fanisovna Mukhammadiyeva; Akhat Barievich Bakirov
Journal:  Int J Occup Environ Med       Date:  2020-01
  6 in total

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