| Literature DB >> 21783916 |
Hamadi Fetoui1, El Mouldi Garoui, Fatma Makni-Ayadi, Najiba Zeghal.
Abstract
The objective of this study was to investigate the propensity of lambda-cyhalothrin (LTC) to induce oxidative stress in blood and brain of male Wistar rats and its possible attenuation by vitamin C. Rats were randomly divided into four groups: group I served as control rats. group II was treated daily with 200mgvit C/(kgbw) administered by intraperitoneal way. Rats of group III have received orally 668ppm LTC. Animals of group IV were treated with LTC and vitamin C. A decrease of some hematologic parameters (RBC, Hb, Ht: p<0.01) and a significant increase of MDA levels (p<0.05) in erythrocytes and brain were observed in LTC group compared to controls. Antioxidant enzyme activities in both tissues were modified in LTC group compared to controls. Administration of vitamin C ameliorated these parameters. Our results indicated the potential effects of LTC to induce oxidative damage in tissues and the ability of vitamin C to attenuate LTC-induced oxidative damage.Entities:
Year: 2008 PMID： 21783916 DOI： 10.1016/j.etap.2008.04.002
Source DB: PubMed Journal: Environ Toxicol Pharmacol ISSN： 1382-6689 Impact factor: 4.860