| Literature DB >> 21783664 |
Nevin Uner1, Elif Özcan Oruç, Yusuf Sevgiler, Nesli Sahin, Hülya Durmaz, Demet Usta.
Abstract
The aim of this study was to investigate the effects of organophosphorus (OP) pesticide diazinon on acetylcholinesterase (AChE: EC 3.1.1.7) activity and its relationship to lipid peroxidation (LPO) in the brain of a freshwater fish, Oreochromis niloticus. Malondialdehyde (MDA) content was used as biomarker for LPO. Fish were exposed to 1 and 2mg/L sublethal concentrations of diazinon for 1, 7, 15 and 30 days. In the entire experimental group, AChE activity in brain significantly decreased (up to 93% of control), whereas MDA content decreased after 1 day, and increased after 7 and 15 days of exposures. MDA was in similar level with the control group after diazinon exposure of 30 days. The findings of the present study show that diazinon inhibited AChE activity and it has LPO-inducing potential in fish. The inhibition of AChE activity in the brain of O. niloticus correlated with increased MDA levels after 7 and 15 days diazinon exposures (r=-0.661, P<0.019; r=-0.652, P<0.022, respectively).Entities:
Year: 2005 PMID： 21783664 DOI： 10.1016/j.etap.2005.08.007
Source DB: PubMed Journal: Environ Toxicol Pharmacol ISSN： 1382-6689 Impact factor: 4.860