Manganese exposure and age: neurobehavioral performance among alloy production workers.

Manganese (Mn) is associated with neurotoxic effects under certain conditions of exposure. A recent study on environmental Mn exposure showed an Mn×age interaction for several neurobehavioral functions. The objective of the present study was to examine the neurobehavioral test results in relation to age and Mn exposure, using an existing data set on 74 workers from an Mn alloy production plant and referents pair-matched for age (±3 years), educational level (±2 years), number of children, and smoking status. The pair differences between Mn-exposed workers and referents increased significantly with age for scores on Delayed Word Recall, Trail Making B, Cancellation H, Nine-Hole Hand Steadiness Test, and Vibratometer. These results suggest that for certain neurobehavioral functions, and in particular for information processing, Mn-related deficits increase with age. This outcome could not be explained by higher cumulative Mn exposure.