Literature DB >> 2178316

The effect of conjugated equine estrogens on ovariectomy-induced osteopenia in the rat.

M A Hayward1, Y P Kharode, M M Becci, D Kowal.   

Abstract

The effect of estrogen replacement on ovariectomy-induced bone loss was evaluated in mature Sprague-Dawley rats. Undecalcified tibia of ovariectomized rats were processed for quantitative histologic assessment of cancellous bone in longitudinal sections from the primary and secondary spongiosa of the proximal metaphysis. Bone content in tissue specimens was quantified as the parameter B. Ar, two-dimensional bone mineral area. Estrogen, supplied as orally administered conjugated equine estrogens, prevented bone loss through 6 weeks of treatment. The effect of conjugated equine estrogens was dose-dependent, with significant protection against bone loss observed at doses of 10 micrograms/kg/day and higher.

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Year:  1990        PMID： 2178316     DOI： 10.1007/BF02003236

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  19 in total

1.  Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee.

Authors:  A M Parfitt; M K Drezner; F H Glorieux; J A Kanis; H Malluche; P J Meunier; S M Ott; R R Recker
Journal:  J Bone Miner Res       Date:  1987-12       Impact factor: 6.741

2.  Osteoporosis after oophorectomy in the mature female rat and the effect of oestrogen and-or progestogen replacement therapy in its prevention.

Authors:  J M Aitken; E Armstrong; J B Anderson
Journal:  J Endocrinol       Date:  1972-10       Impact factor: 4.286

Review 3.  Trabecular bone architecture in the pathogenesis and prevention of fracture.

Authors:  A M Parfitt
Journal:  Am J Med       Date:  1987-01-26       Impact factor: 4.965

4.  Tamoxifen inhibits osteoclast-mediated resorption of trabecular bone in ovarian hormone-deficient rats.

Authors:  R T Turner; G K Wakley; K S Hannon; N H Bell
Journal:  Endocrinology       Date:  1988-03       Impact factor: 4.736

5.  The minimum effective dose of estrogen for prevention of postmenopausal bone loss.

Authors:  R Lindsay; D M Hart; D M Clark
Journal:  Obstet Gynecol       Date:  1984-06       Impact factor: 7.661

6.  Hip fracture and the use of estrogens in postmenopausal women. The Framingham Study.

Authors:  D P Kiel; D T Felson; J J Anderson; P W Wilson; M A Moskowitz
Journal:  N Engl J Med       Date:  1987-11-05       Impact factor: 91.245

7.  Improvements in dehydration and cement line staining for methacrylate embedded human bone biopsies.

Authors:  H E Gruber; G J Marshall; M E Kirchen; J Kang; S G Massry
Journal:  Stain Technol       Date:  1985-11

8.  Skeletal alterations in ovariectomized rats.

Authors:  T J Wronski; P L Lowry; C C Walsh; L A Ignaszewski
Journal:  Calcif Tissue Int       Date:  1985-05       Impact factor: 4.333

9.  The effects of ovariectomy and 17 beta-estradiol on cortical bone histomorphometry in growing rats.

Authors:  R T Turner; J J Vandersteenhoven; N H Bell
Journal:  J Bone Miner Res       Date:  1987-04       Impact factor: 6.741

10.  Post-menopausal estrogen replacement: the prevention of osteoporosis and systemic effects.

Authors:  F W Lafferty; D O Helmuth
Journal:  Maturitas       Date:  1985-07       Impact factor: 4.342
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  4 in total

1.  Effect of weight manipulation on bone loss due to ovariectomy and the protective effects of estrogen in the rat.

Authors:  R E Roudebush; D E Magee; D N Benslay; A M Bendele; H U Bryant
Journal:  Calcif Tissue Int       Date:  1993-07       Impact factor: 4.333

2.  Loss of cancellous bone mass and connectivity in ovariectomized rats can be restored by combined treatment with parathyroid hormone and estradiol.

Authors:  V Shen; D W Dempster; R Birchman; R Xu; R Lindsay
Journal:  J Clin Invest       Date:  1993-06       Impact factor: 14.808

3.  Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study.

Authors:  Mohamed Abdalla Estai; Farihah Haji Suhaimi; Srijit Das; Fazalina Mohd Fadzilah; Sharifah Majedah Idrus Alhabshi; Ahmad Nazrun Shuid; Ima-Nirwana Soelaiman
Journal:  Clinics (Sao Paulo)       Date:  2011       Impact factor: 2.365

4.  Histological changes in the fracture callus following the administration of water extract of piper sarmentosum (daun kadok) in estrogen-deficient rats.

Authors:  Mohamed Abdalla Estai; Ima Nirwana Soelaiman; Ahmad Nazrun Shuid; Srijit Das; Aishah Mohd Ali; Farihah Hj Suhaimi
Journal:  Iran J Med Sci       Date:  2011-12
  4 in total

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