Literature DB >> 21782844

Synthesis and characterization of pH-dependent glycol chitosan and dextran sulfate nanoparticles for effective brain cancer treatment.

Mohammad Reza Saboktakin1, Roya M Tabatabaie, Abel Maharramov, Mohammad Ali Ramazanov.   

Abstract

A novel drug delivery system for the treatment of brain tumors was formulated by methotrexate (MTX)-loaded polymeric nanoparticles (NPs) based on Glycol chitosan (GCS) and Dextran sulfate (DS). The physicochemical properties of resulting particles were investigated, evidencing the contribution of these nanoparticles for brain targeting. In vitro release of MTX was also evaluated. The GCS-DS nanoparticles have been developed based on the modulation of ratio show promise as a system for controlled delivery of the drug to the brain.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21782844     DOI： 10.1016/j.ijbiomac.2011.07.006

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  4 in total

1.  Synthesis and characterization of thiolated carboxymethyl chitosan-graft-cyclodextrin nanoparticles as a drug delivery vehicle for albendazole.

Authors:  Ghazaleh Alamdarnejad; Alireza Sharif; Shahrouz Taranejoo; Mohsen Janmaleki; Mohammad Reza Kalaee; Mohsen Dadgar; Mazyar Khakpour
Journal:  J Mater Sci Mater Med       Date:  2013-05-12       Impact factor: 3.896

2.  Production and Characterization of Chitosan-Polyanion Nanoparticles by Polyelectrolyte Complexation Assisted by High-Intensity Sonication for the Modified Release of Methotrexate.

Authors:  Yhors Ciro; John Rojas; Maria J Alhajj; Gustavo A Carabali; Constain H Salamanca
Journal:  Pharmaceuticals (Basel)       Date:  2020-01-08

3.  Preparation and functional studies of hydroxyethyl chitosan nanoparticles loaded with anti-human death receptor 5 single-chain antibody.

Authors:  Jingjing Yang; Xiaoping Huang; Fanghong Luo; Xiaofeng Cheng; Lianna Cheng; Bin Liu; Lihong Chen; Ruyi Hu; Chunyan Shi; Guohong Zhuang; Ping Yin
Journal:  Onco Targets Ther       Date:  2014-05-21       Impact factor: 4.147

4.  Multicomponent, peptide-targeted glycol chitosan nanoparticles containing ferrimagnetic iron oxide nanocubes for bladder cancer multimodal imaging.

Authors:  Jaehong Key; Deepika Dhawan; Christy L Cooper; Deborah W Knapp; Kwangmeyung Kim; Ick Chan Kwon; Kuiwon Choi; Kinam Park; Paolo Decuzzi; James F Leary
Journal:  Int J Nanomedicine       Date:  2016-08-29
  4 in total

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