Review of neurobehavioral deficits and river fish consumption from the Tapajós (Brazil) and St. Lawrence (Canada).

Our research group is carrying out studies on neurobehavioral changes associated with eating fish from the Upper St. Lawrence River (Québec, Canada) and the Lower Tapajós River (Brazilian Amazon). Here, these studies are reviewed with respect to exposure, effects and intervention. Although mercury (Hg) levels in piscivorous fish are similar in both regions, in the Amazon, fish constitutes the dietary mainstay, while in Quebec, fish consumption is primarily occasional. Mercury exposure of Amazonian fish-eaters was considerably higher than Québec (median blood total Hg: 28 and 1 μg/l, respectively), but fish from the St. Lawrence contain multiple contaminants. For the Tapajós River, increasing hair Hg was associated with reduced motor and visual functions. Comparison of neurobehavioral performance of Québec fish-eaters and non fish-eaters showed a consistent pattern of information processing slowing among the former; these deficits were not related to blood methyl Hg levels. Early changes associated with exposure can be used to trigger intervention. Since fish provide important essential nutrients, mitigation must balance the beneficial and harmful effects. In Canada, advisories from environmental and health agencies consider both these aspects. In the Amazon, we are currently involved in a participatory research whose goal is to reduce Hg absorption, while maintaining fish consumption.