| Literature DB >> 21782004 |
Carolina Jaquenod De Giusti1, Lucrecia Alberdi, Jesica Frik, María F Ferrer, Emilia Scharrig, Mirta Schattner, Ricardo M Gomez.
Abstract
Argentine haemorrhagic fever (AHF) is a systemic febrile syndrome characterized by several haematological and neurological alterations caused by Junín virus (JUNV), a member of the Arenaviridae family. Newborn mice are highly susceptible to JUNV and the course of infection has been associated with the viral strain used. Galectin-3 (Gal-3) is an animal lectin that has been proposed to play an important role in some central nervous system (CNS) diseases. In this study, we analysed Gal-3 expression at the transcriptional and translational expression levels during JUNV-induced CNS disease. We found that Candid 1 strain induced, with relatively low mortality, a subacute/chronic CNS disease with significant glia activation and upregulation of Gal-3 in microglia cells as well as in reactive astrocytes that correlated with viral levels. Our results suggest an important role for Gal-3 in viral-induced CNS disease.Entities:
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Year: 2011 PMID： 21782004 DOI： 10.1016/j.neulet.2011.07.007
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046