| Literature DB >> 21781992 |
Kunitoshi Yamanaka1, Yohei Sasagawa, Teru Ogura.
Abstract
p97/VCP/Cdc48 is one of the best-characterized type II AAA (ATPases associated with diverse cellular activities) ATPases. p97 is suggested to be a ubiquitin-selective chaperone and its key function is to disassemble protein complexes. p97 is involved in a wide variety of cellular activities. Recently, novel functions, namely autophagy and mitochondrial quality control, for p97 have been uncovered. p97 was identified as a causative factor for inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD) and more recently as a causative factor for amyotrophic lateral sclerosis (ALS). In this review, we will summarize and discuss recent progress and topics in p97 functions and the relationship to its associated diseases.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21781992 DOI： 10.1016/j.bbamcr.2011.07.001
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002