| Literature DB >> 21780665 |
S Ia Loginova, S V Borisevich, V A Maksimov, V P Bondarev, S K Kotovskaia, V L Rusinov, V N Charushin, O N Chupakhin.
Abstract
Therapeutic activity of Triazavirin against experimental influenza A was studied on albino mice intranazally infected with influenza virus A/Chicken/Kurgan/Russia/02/05 (H5N1) vs. reference drugs (Oseltamivir, Remantadin and Arbidol). The study showed that in a therapeutic dose of 1 mg/kg Triazavirin was efficient in protection of the animals from death. Its protective therapeutic efficacy (36.7+/-1.7%) was close to that of Oseltamivir (50.0+/-0.0%), comparable with that of Remantadin (38.3+/-1.7%) and higher than that of Arbidol (11.7+/-1.7%). During the whole observation period (up to the terminal phase) Triazavirin inhibited the influenza virus A accumulation in the lungs of the infected albino mice by more than 3 lg.Entities:
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Year: 2011 PMID： 21780665
Source DB: PubMed Journal: Antibiot Khimioter ISSN： 0235-2990