BACKGROUND: In heart failure with preserved ejection fraction (HFPEF), physiological abnormalities are not solely restricted to diastolic function. Because the tissue Doppler imaging (TDI)-derived myocardial performance index (MPI) offers the advantage of recording systolic and diastolic tissue velocity simultaneously in the same cardiac cycle, this study aimed to determine whether TDI-MPI is an informative index for assessing HFPEF, compared with conventional echo parameters. HYPOTHESIS: In patients with HFPEF, TDI-MPI would be an independent predictor for adverse cardiac events. METHODS: Among 408 patients who had diastolic dysfunction without heart failure (HF) or HFPEF, cardiac function was evaluated by mitral flow (MF) or TDI-MPI. During the median follow-up of 32 months, clinical outcomes, which were defined as the composite of cardiovascular death and admission for HF, were assessed. RESULTS: Mean MF and TDI-MPI were significantly greater in the HFPEF group. TDI-MPI rather than MF had a significant correlation with N-terminal pro-brain natriuretic peptide level. The area under the receiver operating characteristic curve of TDI-MPI for the detection of HFPEF was 0.86. With regard to clinical outcomes, 31 events were identified during follow-up periods. On a multivariate analysis, TDI-MPI >0.66 was the best prognostic predictor of events and provided incremental predictive value. CONCLUSIONS: Compared to MF-MPI, TDI-MPI may be a more useful parameter for the evaluation of patients with HFPEF.
BACKGROUND: In heart failure with preserved ejection fraction (HFPEF), physiological abnormalities are not solely restricted to diastolic function. Because the tissue Doppler imaging (TDI)-derived myocardial performance index (MPI) offers the advantage of recording systolic and diastolic tissue velocity simultaneously in the same cardiac cycle, this study aimed to determine whether TDI-MPI is an informative index for assessing HFPEF, compared with conventional echo parameters. HYPOTHESIS: In patients with HFPEF, TDI-MPI would be an independent predictor for adverse cardiac events. METHODS: Among 408 patients who had diastolic dysfunction without heart failure (HF) or HFPEF, cardiac function was evaluated by mitral flow (MF) or TDI-MPI. During the median follow-up of 32 months, clinical outcomes, which were defined as the composite of cardiovascular death and admission for HF, were assessed. RESULTS: Mean MF and TDI-MPI were significantly greater in the HFPEF group. TDI-MPI rather than MF had a significant correlation with N-terminal pro-brain natriuretic peptide level. The area under the receiver operating characteristic curve of TDI-MPI for the detection of HFPEF was 0.86. With regard to clinical outcomes, 31 events were identified during follow-up periods. On a multivariate analysis, TDI-MPI >0.66 was the best prognostic predictor of events and provided incremental predictive value. CONCLUSIONS: Compared to MF-MPI, TDI-MPI may be a more useful parameter for the evaluation of patients with HFPEF.
Authors: Tor Biering-Sørensen; Jan Skov Jensen; Henrik Ullits Andersen; Peter Rossing; Magnus Thorsten Jensen Journal: Int J Cardiovasc Imaging Date: 2016-01-21 Impact factor: 2.357
Authors: Aura A Sanchez Mejia; Kathleen E Simpson; Charles F Hildebolt; Elfriede Pahl; Kathleen L Matthews; Cheryl A Rainey; Charles E Canter; Patrick Y Jay; Mark C Johnson Journal: Pediatr Cardiol Date: 2013-09-24 Impact factor: 1.655
Authors: Keyvan Yousefi; Camila I Irion; Lauro M Takeuchi; Wen Ding; Guerline Lambert; Trevor Eisenberg; Sarah Sukkar; Henk L Granzier; Mei Methawasin; Dong I Lee; Virginia S Hahn; David A Kass; Konstantinos E Hatzistergos; Joshua M Hare; Keith A Webster; Lina A Shehadeh Journal: J Am Coll Cardiol Date: 2019-06-04 Impact factor: 24.094