A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles.

A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level. This journal is © The Royal Society of Chemistry 2011