Alexis Lacout1, Pierre Yves Marcy, Guy Lesec. 1. Centre d'imagerie médicale, Centre médico chirurgical (CMC) - groupe VITALIA, Aurillac, Clermont-Ferrand, France.
Abstract
BACKGROUND: The stromal reaction may be one of the key factors in the development of breast carcinomas. CASE REPORT: We report the case of an 80-year-old female patient who ignored a very slow growing, extensive scirrhous breast carcinoma for almost 20 years duration. RESULTS: Histopathology analysis revealed a Scarff Bloom Richardson (SBR)3-grade, estrogen receptor (ER)-positive (80%), progesterone receptor (PR)-positive (10%), HER2/neu-negative, lobular-invasive, scirrhous breast carcinoma with large cells. CONCLUSION: A strong peritumoral fibrous stromal reaction may explain the longstanding evolution of the tumor without any distant metastases.
BACKGROUND: The stromal reaction may be one of the key factors in the development of breast carcinomas. CASE REPORT: We report the case of an 80-year-old female patient who ignored a very slow growing, extensive scirrhous breast carcinoma for almost 20 years duration. RESULTS: Histopathology analysis revealed a Scarff Bloom Richardson (SBR)3-grade, estrogen receptor (ER)-positive (80%), progesterone receptor (PR)-positive (10%), HER2/neu-negative, lobular-invasive, scirrhous breast carcinoma with large cells. CONCLUSION: A strong peritumoral fibrous stromal reaction may explain the longstanding evolution of the tumor without any distant metastases.
Authors: Robert B West; Dimitry S A Nuyten; Subbaya Subramanian; Torsten O Nielsen; Christopher L Corless; Brian P Rubin; Kelli Montgomery; Shirley Zhu; Rajiv Patel; Tina Hernandez-Boussard; John R Goldblum; Patrick O Brown; Marc van de Vijver; Matt van de Rijn Journal: PLoS Biol Date: 2005-05-10 Impact factor: 8.029