Literature DB >> 21779057

Why are multi-centre clinical observational studies still so difficult to run?

J Sandy1, N Kilpatrick, M Persson, A Bessel, A Waylen, A Ness, A Ireland.   

Abstract

Despite the introduction of IRAS, obtaining R&D approvals for multicentre studies is a major rate limiting step. Our experience with cleft research demonstrates that this approvals process must be drastically and rapidly improved if we wish to continue attract clinical research to the UK.

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Year:  2011        PMID： 21779057     DOI： 10.1038/sj.bdj.2011.570

Source DB:  PubMed          Journal:  Br Dent J        ISSN： 0007-0610            Impact factor:   1.626


  7 in total

1.  Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000.

Authors:  Andrew Robert Ness; Andrea Waylen; Katrina Hurley; Mona Jeffreys; Chris Penfold; Miranda Pring; Sam Leary; Christine Allmark; Stu Toms; Susan Ring; Tim J Peters; Will Hollingworth; Helen Worthington; Chris Nutting; Sheila Fisher; Simon N Rogers; Steven J Thomas
Journal:  BMC Cancer       Date:  2014-12-17       Impact factor: 4.430

2.  Huge variation in obtaining ethical permission for a non-interventional observational study in Europe.

Authors:  Dylan W de Lange; Bertrand Guidet; Finn H Andersen; Antonio Artigas; Guidio Bertolini; Rui Moreno; Steffen Christensen; Maurizio Cecconi; Christina Agvald-Ohman; Primoz Gradisek; Christian Jung; Brian J Marsh; Sandra Oeyen; Bernardo Bollen Pinto; Wojciech Szczeklik; Ximena Watson; Tilemachos Zafeiridis; Hans Flaatten
Journal:  BMC Med Ethics       Date:  2019-06-03       Impact factor: 2.652

3.  Satisfactory clinical and radiologic outcomes with a new shorter and modular stem for end-stage hip osteoarthritis: an international prospective multicentre pilot study.

Authors:  Riccardo D'Ambrosi; Aldo Toni; Jaroslaw Czubak; Jorge Guadilla; Lawrence Lieber; Ilaria Mariani; Nicola Ursino
Journal:  SICOT J       Date:  2022-04-04

4.  Double-counting of populations in evidence synthesis in public health: a call for awareness and future methodological development.

Authors:  Humaira Hussein; Clareece R Nevill; Anna Meffen; Keith R Abrams; Sylwia Bujkiewicz; Alex J Sutton; Laura J Gray
Journal:  BMC Public Health       Date:  2022-09-27       Impact factor: 4.135

5.  Centralization of cleft care in the UK. Part 6: a tale of two studies.

Authors:  A R Ness; A K Wills; A Waylen; R Al-Ghatam; T E M Jones; R Preston; A J Ireland; M Persson; J Smallridge; A J Hall; D Sell; J R Sandy
Journal:  Orthod Craniofac Res       Date:  2015-11       Impact factor: 1.826

6.  Opening research sites in multicentre clinical trials within the UK: a detailed analysis of delays.

Authors:  Anna Kearney; Andrew McKay; Helen Hickey; Silviya Balabanova; Anthony G Marson; Carrol Gamble; Paula Williamson
Journal:  BMJ Open       Date:  2014-09-16       Impact factor: 2.692

7.  A cross-sectional survey of 5-year-old children with non-syndromic unilateral cleft lip and palate: the Cleft Care UK study. Part 1: background and methodology.

Authors:  M Persson; J R Sandy; A Waylen; A K Wills; R Al-Ghatam; A J Ireland; A J Hall; W Hollingworth; T Jones; T J Peters; R Preston; D Sell; J Smallridge; H Worthington; A R Ness
Journal:  Orthod Craniofac Res       Date:  2015-11       Impact factor: 1.826
  7 in total

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