| Literature DB >> 2177868 |
N L Harrison1, D M Lovinger, N A Lambert, T J Teyler, R Prager, J Ong, D I Kerr.
Abstract
The actions of 2-hydroxy-saclofen (2-OH-S), a recently developed analog of baclofen, were studied at presynaptic GABAB receptors in the rat hippocampal slice. Baclofen (0.5-20 microM) reduces the amplitude of excitatory postsynaptic potentials (EPSPs) recorded from hippocampal CA1 pyramidal neurons. In the presence of 200-500 microM 2-OH-S, the synaptic depressant action of baclofen is significantly reduced. These data show that 2-OH-S is an effective antagonist at presynaptic GABAB receptors on excitatory terminals in the hippocampus.Entities:
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Year: 1990 PMID： 2177868 DOI： 10.1016/0304-3940(90)90851-y
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046