Literature DB >> 21778384

Comment on "Activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine".

Kenneth M Murphy1.   

Abstract

Manicassamy et al. (Reports, 13 August 2010, p. 849) deleted β-catenin in intestinal immune cells using a CD11c-driven Cre recombinase, which decreased anti-inflammatory mediators and increased inflammatory bowel disease. However, the deletion of β-catenin in macrophages remains a caveat to their interpretation that Wnt signaling programs dendritic cells into a tolerogenic state. Development of strains expressing Cre in a more finely lineage-restricted pattern may help resolve this issue.

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Year:  2011        PMID： 21778384     DOI： 10.1126/science.1198277

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

Review 1.  Re(de)fining the dendritic cell lineage.

Authors:  Ansuman T Satpathy; Xiaodi Wu; Jörn C Albring; Kenneth M Murphy
Journal:  Nat Immunol       Date:  2012-11-16       Impact factor: 25.606

Review 2.  Protective and pathogenic functions of macrophage subsets.

Authors:  Peter J Murray; Thomas A Wynn
Journal:  Nat Rev Immunol       Date:  2011-10-14       Impact factor: 53.106

3.  Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.

Authors:  Matthew M Meredith; Kang Liu; Guillaume Darrasse-Jeze; Alice O Kamphorst; Heidi A Schreiber; Pierre Guermonprez; Juliana Idoyaga; Cheolho Cheong; Kai-Hui Yao; Rachel E Niec; Michel C Nussenzweig
Journal:  J Exp Med       Date:  2012-05-21       Impact factor: 14.307

4.  Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.

Authors:  Ansuman T Satpathy; Wumesh KC; Jörn C Albring; Brian T Edelson; Nicole M Kretzer; Deepta Bhattacharya; Theresa L Murphy; Kenneth M Murphy
Journal:  J Exp Med       Date:  2012-05-21       Impact factor: 14.307

5.  Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid.

Authors:  R Zeng; M Bscheider; K Lahl; M Lee; E C Butcher
Journal:  Mucosal Immunol       Date:  2015-07-01       Impact factor: 7.313

Review 6.  Contribution of Basophils to Cutaneous Immune Reactions and Th2-Mediated Allergic Responses.

Authors:  Atsushi Otsuka; Kenji Kabashima
Journal:  Front Immunol       Date:  2015-08-03       Impact factor: 7.561

7.  Critical Role of Alternative M2 Skewing in miR-155 Deletion-Mediated Protection of Colitis.

Authors:  Jintao Li; Ji Zhang; Hongxia Guo; Shimin Yang; Weiping Fan; Nan Ye; Zhiqiang Tian; Tiantian Yu; Guoping Ai; Zigang Shen; Haiyang He; Ping Yan; Hui Lin; Xue Luo; Hongli Li; Yuzhang Wu
Journal:  Front Immunol       Date:  2018-05-03       Impact factor: 7.561
  7 in total

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