Literature DB >> 21777273

Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels.

Gohar Fakhfouri1, Reza Rahimian, Saeed Hashemi, Mohammad Reza Rasouli, Arash Bahremand, Shahram Ejtemaei Mehr, Mohammad Reza Khorramizadeh, Ahmad Reza Dehpour.   

Abstract

The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP-sensitive potassium channels (KATP) and cGMP, respectively.

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Year:  2012        PMID： 21777273     DOI： 10.1111/j.1472-8206.2011.00928.x

Source DB:  PubMed          Journal:  Fundam Clin Pharmacol        ISSN： 0767-3981            Impact factor:   2.748


  4 in total

1.  Phosphodiesterase-5 inhibition suppresses colonic inflammation-induced tumorigenesis via blocking the recruitment of MDSC.

Authors:  Shiyong Lin; Jing Wang; Lihui Wang; Jing Wen; Yandong Guo; Weiguang Qiao; Jieqiong Zhou; Guoliang Xu; Fachao Zhi
Journal:  Am J Cancer Res       Date:  2017-01-01       Impact factor: 6.166

2.  The pro-inflammatory cytokine TNF-α inhibits lymphatic pumping via activation of the NF-κB-iNOS signaling pathway.

Authors:  Yingxuan Chen; Sonia Rehal; Simon Roizes; Hai-Lei Zhu; William C Cole; Pierre-Yves von der Weid
Journal:  Microcirculation       Date:  2017-04       Impact factor: 2.628

Review 3.  Research progress of phosphodiesterase inhibitors in inflammatory bowel disease treatment.

Authors:  Jianrong Shi; Wangqian Ma; Huifang Tang
Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban       Date:  2021-10-25

4.  The effect of montelukast, a leukotriene receptor antagonist, on the acetic acid-induced model of colitis in rats: Involvement of NO-cGMP-KATP channels pathway.

Authors:  Behnam Ghorbanzadeh; Mohammad Amin Behmanesh; Roya Mahmoudinejad; Mehdi Zamaniyan; Shadi Ekhtiar; Yousef Paridar
Journal:  Front Pharmacol       Date:  2022-09-26       Impact factor: 5.988
  4 in total

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