Literature DB >> 21777142

The role of nitric oxide in the physiology and pathophysiology of the exocrine pancreas.

Péter Hegyi1, Zoltán Rakonczay.   

Abstract

SIGNIFICANCE: Nitric oxide (NO), a ubiquitous gaseous signaling molecule, contributes to both pancreatic physiology and pathophysiology. RECENT ADVANCES: The present review provides a general overview of NO synthesis, signaling, and function. Further, it specifically discusses NO metabolism and its effects in the exocrine pancreas and focuses on the role of NO in the pathogenesis of acute pancreatitis and pancreatic ischemia/reperfusion injury. CRITICAL ISSUES: Unfortunately, the role of NO in pancreatic physiology and pathophysiology remains controversial in numerous areas. Many questions regarding the messenger molecule still remain unanswered. FUTURE DIRECTIONS: Probably the least is known about the downstream targets of NO, which need to be identified, especially at the molecular level.

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Year:  2011        PMID： 21777142     DOI： 10.1089/ars.2011.4063

Source DB:  PubMed          Journal:  Antioxid Redox Signal        ISSN： 1523-0864            Impact factor:   8.401


  10 in total

Review 1.  High-mobility group box 1 protein and its role in severe acute pancreatitis.

Authors:  Xiao Shen; Wei-Qin Li
Journal:  World J Gastroenterol       Date:  2015-02-07       Impact factor: 5.742

2.  Necrotic amplification loop in acute pancreatitis: pancreatic stellate cells and nitric oxide are important players in the development of the disease.

Authors:  Péter Hegyi
Journal:  J Physiol       Date:  2018-04-19       Impact factor: 5.182

Review 3.  Pharmacologic therapy for acute pancreatitis.

Authors:  Swetha Kambhampati; Walter Park; Aida Habtezion
Journal:  World J Gastroenterol       Date:  2014-12-07       Impact factor: 5.742

Review 4.  Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents.

Authors:  Balázs Kui; Zsolt Balla; Eszter T Végh; Petra Pallagi; Viktória Venglovecz; Béla Iványi; Tamás Takács; Péter Hegyi; Zoltán Rakonczay
Journal:  Lab Invest       Date:  2013-12-23       Impact factor: 5.662

Review 5.  Remote ischemic preconditioning as treatment for non-ischemic gastrointestinal disorders: beyond ischemia-reperfusion injury.

Authors:  Carlos Rodrigo Camara-Lemarroy
Journal:  World J Gastroenterol       Date:  2014-04-07       Impact factor: 5.742

6.  Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin.

Authors:  Manuel Maglione; Benno Cardini; Rupert Oberhuber; Katrin Watschinger; Marcel Jenny; Johanna Gostner; Martin Hermann; Peter Obrist; Raimund Margreiter; Johann Pratschke; Gerald Brandacher; Ernst R Werner
Journal:  Transpl Int       Date:  2012-07-17       Impact factor: 3.782

Review 7.  The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications.

Authors:  Paulina Dumnicka; Dawid Maduzia; Piotr Ceranowicz; Rafał Olszanecki; Ryszard Drożdż; Beata Kuśnierz-Cabala
Journal:  Int J Mol Sci       Date:  2017-02-08       Impact factor: 5.923

8.  Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation.

Authors:  Monika A Jakubowska; Pawel E Ferdek; Oleg V Gerasimenko; Julia V Gerasimenko; Ole H Petersen
Journal:  Open Biol       Date:  2016-08       Impact factor: 6.411

9.  Nitric Oxide Stimulates Acute Pancreatitis Pain via Activating the NF-κB Signaling Pathway and Inhibiting the Kappa Opioid Receptor.

Authors:  Mengwen Xue; Liang Han; Weikun Qian; Jie Li; Tao Qin; Ying Xiao; Qingyong Ma; Jiguang Ma; Xin Shen
Journal:  Oxid Med Cell Longev       Date:  2020-05-07       Impact factor: 6.543

10.  The clinical course of acute pancreatitis and the inflammatory mediators that drive it.

Authors:  Leena Kylänpää; Zoltán Rakonczay; Derek A O'Reilly
Journal:  Int J Inflam       Date:  2012-12-12
  10 in total

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