Literature DB >> 21776980

ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor.

Conor S Barry1, Keriann M Backus, Clifton E Barry, Benjamin G Davis.   

Abstract

Mycobacterium tuberculosis Antigen 85 enzymes are vital to the integrity of the highly impermeable cell envelope and are potential therapeutic targets. Kinetic analysis using a label-free assay revealed both mechanistic details and a substrate profile that allowed the design and construction of a selective in vitro mechanism-based inhibitor.

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Year:  2011        PMID： 21776980     DOI： 10.1021/ja204249p

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  13 in total

1.  Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo.

Authors:  Albertus Viljoen; Matthias Richard; Phuong Chi Nguyen; Patrick Fourquet; Luc Camoin; Rishi R Paudal; Giri R Gnawali; Christopher D Spilling; Jean-François Cavalier; Stéphane Canaan; Mickael Blaise; Laurent Kremer
Journal:  J Biol Chem       Date:  2018-01-04       Impact factor: 5.157

2.  Tailoring Trehalose for Biomedical and Biotechnological Applications.

Authors:  Mara K O'Neill; Brent F Piligian; Claire D Olson; Peter J Woodruff; Benjamin M Swarts
Journal:  Pure Appl Chem       Date:  2017-01-11       Impact factor: 2.453

3.  Imaging mycobacterial growth and division with a fluorogenic probe.

Authors:  Heather L Hodges; Robert A Brown; John A Crooks; Douglas B Weibel; Laura L Kiessling
Journal:  Proc Natl Acad Sci U S A       Date:  2018-04-27       Impact factor: 11.205

Review 4.  Chemical Reporters for Bacterial Glycans: Development and Applications.

Authors:  Nicholas Banahene; Herbert W Kavunja; Benjamin M Swarts
Journal:  Chem Rev       Date:  2021-12-14       Impact factor: 60.622

5.  Targeting the trehalose utilization pathways of Mycobacterium tuberculosis.

Authors:  Sandeep Thanna; Steven J Sucheck
Journal:  Medchemcomm       Date:  2015-10-16       Impact factor: 3.597

Review 6.  Targeting the mycobacterial envelope for tuberculosis drug development.

Authors:  Lorenza Favrot; Donald R Ronning
Journal:  Expert Rev Anti Infect Ther       Date:  2012-09       Impact factor: 5.091

Review 7.  New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics.

Authors:  E Jeffrey North; Mary Jackson; Richard E Lee
Journal:  Curr Pharm Des       Date:  2014       Impact factor: 3.116

8.  Design, synthesis, and X-ray analysis of a glycoconjugate bound to Mycobacterium tuberculosis antigen 85C.

Authors:  Diaa A Ibrahim; Julie Boucau; Daniel H Lajiness; Sri Kumar Veleti; Kevin R Trabbic; Samuel S Adams; Donald R Ronning; Steven J Sucheck
Journal:  Bioconjug Chem       Date:  2012-12-10       Impact factor: 4.774

9.  The three Mycobacterium tuberculosis antigen 85 isoforms have unique substrates and activities determined by non-active site regions.

Authors:  Keriann M Backus; Michael A Dolan; Conor S Barry; Maju Joe; Peter McPhie; Helena I M Boshoff; Todd L Lowary; Benjamin G Davis; Clifton E Barry
Journal:  J Biol Chem       Date:  2014-07-14       Impact factor: 5.157

Review 10.  Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target.

Authors:  Katherine A Abrahams; Gurdyal S Besra
Journal:  Parasitology       Date:  2016-12-15       Impact factor: 3.234
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