Literature DB >> 2177683

Comparison of pharmacological effects of tetrahydrocannabinols and their 11-hydroxy-metabolites in mice.

K Watanabe1, T Kijima, S Narimatsu, J Nishikami, I Yamamoto, H Yoshimura.   

Abstract

Pharmacological effects (catalepsy, hypothermia, pentobarbital-induced sleep prolongation, anticonvulsant and analgesic effects) of delta 8- and delta 9-tetrahydrocannabinols, and their 11-hydroxy-metabolites were evaluated and compared in mice. delta 9-Tetrahydrocannabinol and 11-hydroxy-delta 9-tetrahydrocannabinol exhibited somewhat greater effects than did delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol, respectively, in all pharmacological indices tested. Greater effects of 11-hydroxy-metabolites than those of tetrahydrocannabinols were also demonstrated.

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Year:  1990        PMID： 2177683     DOI： 10.1248/cpb.38.2317

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  3 in total

1.  Examining impairment and kinetic patterns associated with recent use of hemp-derived Δ8-tetrahydrocannabinol: case studies.

Authors:  Gregory T Wurz; Edward Montoya; Michael W DeGregorio
Journal:  J Cannabis Res       Date:  2022-07-07

Review 2.  The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.

Authors:  R G Pertwee
Journal:  Br J Pharmacol       Date:  2007-09-10       Impact factor: 8.739

3.  Sex, species and age: Effects of rodent demographics on the pharmacology of ∆9-tetrahydrocanabinol.

Authors:  Jenny L Wiley; Daniel G Barrus; Charlotte E Farquhar; Timothy W Lefever; Thomas F Gamage
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2020-08-15       Impact factor: 5.067
  3 in total

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