| Literature DB >> 21775517 |
Roberto Calcedo1, Hiroki Morizono, Lili Wang, Robert McCarter, Jianping He, David Jones, Mark L Batshaw, James M Wilson.
Abstract
Neutralizing antibodies (NAb) to an adeno-associated virus (AAV) vector due to previous natural infection with wild-type AAV can significantly limit gene transfer. NAb titers to AAV serotype 2 (AAV2) and AAV8 in human subjects (0 to 18 years) were studied. NAb prevalence is moderate at birth, decreases markedly from 7 to 11 months, and then progressively increases through childhood and adolescence.Entities:
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Year: 2011 PMID: 21775517 PMCID: PMC3165215 DOI: 10.1128/CVI.05107-11
Source DB: PubMed Journal: Clin Vaccine Immunol ISSN: 1556-679X