BACKGROUND: Identifying patients with heart failure (HF) who are at risk of experiencing symptomatic adverse drug events (ADEs) is important for improving patient care and quality of life. Several demographic and clinical variables have been identified as potential risk factors for ADEs but limited knowledge is available on the impact of HF patients' beliefs and perceptions on their experience of ADEs. OBJECTIVE: The purpose of the study was to identify the relationship between HF patients' illness perception and medication beliefs and self-reported ADEs. DESIGN: A cross-sectional survey was performed between November 2008 and March 2009. SETTINGS: One university medical centre, two regional hospitals and 20 general practitioners in the Netherlands participated in the study. PARTICIPANTS: 495 patients with HF were included. METHODS: Patients completed the validated Revised Illness Perception Questionnaire (IPQ-R) and the Beliefs about Medication Questionnaire (BMQ) which collected data on their illness perception and medication beliefs. In addition, data on ADEs as experienced in the previous four weeks were collected through an open-ended question and a symptom checklist. Multivariate logistic regression was performed to identify factors associated with these ADEs. RESULTS: In total, 332 (67%) patients had experienced ADEs in the previous four weeks, of whom 28% reported dry mouth, 27% dizziness and 19% itchiness as the most prevalent. In the adjusted multivariate analysis, disease-related symptoms (illness identity) (OR for 1-5 symptoms 3.57; 95% CI 2.22-5.75, OR for >5 symptoms 7.37; 95% CI 3.44-15.8), and general beliefs about medication overuse (OR 1.07; 95% CI 1.01-1.13) were independently associated with experiencing ADEs, whereas none of the demographic or clinical factors were significant. CONCLUSIONS: HF patients who perceive a high number of disease symptoms and have negative medication beliefs are at higher risk of experiencing self-reported ADEs. We suggest that future studies and interventions to improve ADE management should focus on negative medication beliefs and assisting patients in differentiating disease symptoms from ADEs. 2011. Published by Elsevier Ltd.
BACKGROUND: Identifying patients with heart failure (HF) who are at risk of experiencing symptomatic adverse drug events (ADEs) is important for improving patient care and quality of life. Several demographic and clinical variables have been identified as potential risk factors for ADEs but limited knowledge is available on the impact of HF patients' beliefs and perceptions on their experience of ADEs. OBJECTIVE: The purpose of the study was to identify the relationship between HF patients' illness perception and medication beliefs and self-reported ADEs. DESIGN: A cross-sectional survey was performed between November 2008 and March 2009. SETTINGS: One university medical centre, two regional hospitals and 20 general practitioners in the Netherlands participated in the study. PARTICIPANTS: 495 patients with HF were included. METHODS:Patients completed the validated Revised Illness Perception Questionnaire (IPQ-R) and the Beliefs about Medication Questionnaire (BMQ) which collected data on their illness perception and medication beliefs. In addition, data on ADEs as experienced in the previous four weeks were collected through an open-ended question and a symptom checklist. Multivariate logistic regression was performed to identify factors associated with these ADEs. RESULTS: In total, 332 (67%) patients had experienced ADEs in the previous four weeks, of whom 28% reported dry mouth, 27% dizziness and 19% itchiness as the most prevalent. In the adjusted multivariate analysis, disease-related symptoms (illness identity) (OR for 1-5 symptoms 3.57; 95% CI 2.22-5.75, OR for >5 symptoms 7.37; 95% CI 3.44-15.8), and general beliefs about medication overuse (OR 1.07; 95% CI 1.01-1.13) were independently associated with experiencing ADEs, whereas none of the demographic or clinical factors were significant. CONCLUSIONS: HF patients who perceive a high number of disease symptoms and have negative medication beliefs are at higher risk of experiencing self-reported ADEs. We suggest that future studies and interventions to improve ADE management should focus on negative medication beliefs and assisting patients in differentiating disease symptoms from ADEs. 2011. Published by Elsevier Ltd.
Authors: Tiny Jaarsma; Loreena Hill; Antoni Bayes-Genis; Hans-Peter Brunner La Rocca; Teresa Castiello; Jelena Čelutkienė; Elena Marques-Sule; Carla M Plymen; Susan E Piper; Barbara Riegel; Frans H Rutten; Tuvia Ben Gal; Johann Bauersachs; Andrew J S Coats; Ovidiu Chioncel; Yuri Lopatin; Lars H Lund; Mitja Lainscak; Brenda Moura; Wilfried Mullens; Massimo F Piepoli; Giuseppe Rosano; Petar Seferovic; Anna Strömberg Journal: Eur J Heart Fail Date: 2020-10-20 Impact factor: 15.534
Authors: Caleb Ferguson; Sally C Inglis; Phillip J Newton; Sandy Middleton; Peter S Macdonald; Patricia M Davidson Journal: Vasc Health Risk Manag Date: 2013-01-16