Literature DB >> 2177464

Inhibition of phosphatidylinositol kinase by toyocamycin.

H Nishioka1, T Sawa, M Hamada, N Shimura, M Imoto, K Umezawa.   

Abstract

We have screened toyocamycin as an inhibitor of phosphatidylinositol kinase. It inhibited the enzyme of A431 cell membrane with an IC50 of 3.3 micrograms/ml. Adenosine and formycin A also inhibited the enzyme, but other 6 related nucleosides did not. Although orobol and 2,3-dihydroxybenzaldehyde that inhibit phosphatidylinositol kinase inhibited in situ phosphatidylinositol turnover, toyocamycin did not.

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Year:  1990        PMID： 2177464     DOI： 10.7164/antibiotics.43.1586

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

1.  Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis.

Authors:  Junpei Nomura; Hiroshi Hashimoto; Takehiro Ohta; Yoshiteru Hashimoto; Koichi Wada; Yoshinori Naruta; Ken-Ichi Oinuma; Michihiko Kobayashi
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-04       Impact factor: 11.205

Review 2.  Screening and identification of inhibitors of endoplasmic reticulum stress-induced activation of the IRE1α-XBP1 branch.

Authors:  Etsu Tashiro
Journal:  J Antibiot (Tokyo)       Date:  2019-08-09       Impact factor: 2.649

3.  Interaction of Rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activity.

Authors:  Irene N Kiburu; Nicole LaRonde-LeBlanc
Journal:  PLoS One       Date:  2012-05-22       Impact factor: 3.240

Review 4.  Pyrrolo[2,3-d]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides.

Authors:  Pavla Perlíková; Michal Hocek
Journal:  Med Res Rev       Date:  2017-08-23       Impact factor: 12.944

5.  A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity.

Authors:  Maria Yusenko; Anke Jakobs; Karl-Heinz Klempnauer
Journal:  Sci Rep       Date:  2018-09-03       Impact factor: 4.379

6.  Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.

Authors:  M Ri; E Tashiro; D Oikawa; S Shinjo; M Tokuda; Y Yokouchi; T Narita; A Masaki; A Ito; J Ding; S Kusumoto; T Ishida; H Komatsu; Y Shiotsu; R Ueda; T Iwawaki; M Imoto; S Iida
Journal:  Blood Cancer J       Date:  2012-07-20       Impact factor: 11.037

7.  Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.

Authors:  Wejdane El Manaa; Eric Duplan; Thomas Goiran; Inger Lauritzen; Loan Vaillant Beuchot; Sandra Lacas-Gervais; Vanessa Alexandra Morais; Han You; Ling Qi; Mario Salazar; Umut Ozcan; Mounia Chami; Frédéric Checler; Cristine Alves da Costa
Journal:  Autophagy       Date:  2021-05-24       Impact factor: 16.016
  7 in total

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