Literature DB >> 21774606

Behavioral measures of saccade latency and inhibition in manifest and premanifest Huntington's disease.

Travis H Turner1, Jody Goldstein, Joanne M Hamilton, Mark Jacobson, Eva Pirogovsky, Guerry Peavy, Jody Corey-Bloom.   

Abstract

Initiation and inhibition of saccadic eye movements has been shown to be impaired in patients with Huntington's disease (HD) and premanifest gene carriers (PMGC), and may provide biomarkers useful in tracking phenotypic change. Computerized behavioral tests of prosaccade latency and disinhibition presented to 31 non-gene carriers (NGC), 25 PMGC, and 12 HD patients. These tests provided quantitative performance measures without use of eye-tracking equipment. Significant differences on saccade tests were found, with PMGC intermediate between NGC and HD patients. Saccade latency discriminated PMGC from NGC, whereas saccade disinhibition discriminated PMGC from HD patients. Results suggest utility of behavioral saccade measures as premanifest indicators of phenoconversion in HD.

Entities:  

Mesh：

Year:  2011        PMID： 21774606      PMCID： PMC3568932          DOI： 10.1080/00222895.2011.580390

Source DB:  PubMed          Journal:  J Mot Behav        ISSN： 0022-2895            Impact factor:   1.328


  20 in total

1.  Evaluating statistical difference, equivalence, and indeterminacy using inferential confidence intervals: an integrated alternative method of conducting null hypothesis statistical tests.

Authors:  W W Tryon
Journal:  Psychol Methods       Date:  2001-12

2.  Oculomotor control in asymptomatic and recently diagnosed individuals with the genetic marker for Huntington's disease.

Authors:  T M Blekher; R D Yee; S C Kirkwood; A M Hake; J C Stout; M R Weaver; T M Foroud
Journal:  Vision Res       Date:  2004-10       Impact factor: 1.886

3.  Huntington's disease: changes in saccades and hand-tapping over 3 years.

Authors:  Chrystalina A Antoniades; Zheyu Xu; Sarah L Mason; R H S Carpenter; Roger A Barker
Journal:  J Neurol       Date:  2010-06-29       Impact factor: 4.849

4.  Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study.

Authors:  Kevin M Biglan; Christopher A Ross; Douglas R Langbehn; Elizabeth H Aylward; Julie C Stout; Sarah Queller; Noelle E Carlozzi; Kevin Duff; Leigh J Beglinger; Jane S Paulsen
Journal:  Mov Disord       Date:  2009-09-15       Impact factor: 10.338

5.  Visually guided exploration in Huntington disease.

Authors:  C J Lang; F M Reischies; M Majer; R F Daum
Journal:  Cortex       Date:  1999-09       Impact factor: 4.027

6.  Impaired analysis of moving objects due to deficient smooth pursuit eye movements.

Authors:  T Haarmeier; P Thier
Journal:  Brain       Date:  1999-08       Impact factor: 13.501

Review 7.  Ocular motor abnormalities in Huntington's disease.

Authors:  A G Lasker; D S Zee
Journal:  Vision Res       Date:  1997-12       Impact factor: 1.886

8.  Saccadometry of conditional rules in presymptomatic Huntington's disease.

Authors:  Matthieu P A Robert; Parashkev C Nachev; Stephen L Hicks; Charlotte V P Golding; Sarah J Tabrizi; Christopher Kennard
Journal:  Ann N Y Acad Sci       Date:  2009-05       Impact factor: 5.691

9.  Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group.

Authors: 
Journal:  Mov Disord       Date:  1996-03       Impact factor: 10.338

10.  A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length.

Authors:  D R Langbehn; R R Brinkman; D Falush; J S Paulsen; M R Hayden
Journal:  Clin Genet       Date:  2004-04       Impact factor: 4.438
View more
  11 in total

1.  The impact of oculomotor functioning on neuropsychological performance in Huntington disease.

Authors:  Janessa O Carvalho; Jeffrey D Long; Holly J Westervelt; Megan M Smith; Jared M Bruce; Ji-In Kim; James A Mills; Jane S Paulsen
Journal:  J Clin Exp Neuropsychol       Date:  2016       Impact factor: 2.475

Review 2.  Eye movements in patients with neurodegenerative disorders.

Authors:  Tim J Anderson; Michael R MacAskill
Journal:  Nat Rev Neurol       Date:  2013-01-22       Impact factor: 42.937

3.  Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice.

Authors:  Y P Deng; T Wong; C Bricker-Anthony; B Deng; A Reiner
Journal:  Neurobiol Dis       Date:  2013-08-19       Impact factor: 5.996

Review 4.  Disrupted striatal neuron inputs and outputs in Huntington's disease.

Authors:  Anton Reiner; Yun-Ping Deng
Journal:  CNS Neurosci Ther       Date:  2018-04       Impact factor: 5.243

5.  Cholinergic interneurons in the Q140 knockin mouse model of Huntington's disease: Reductions in dendritic branching and thalamostriatal input.

Authors:  Yun-Ping Deng; Anton Reiner
Journal:  J Comp Neurol       Date:  2016-06-06       Impact factor: 3.215

Review 6.  Alterations of eye movement control in neurodegenerative movement disorders.

Authors:  Martin Gorges; Elmar H Pinkhardt; Jan Kassubek
Journal:  J Ophthalmol       Date:  2014-05-18       Impact factor: 1.909

7.  Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease.

Authors:  Yun-Ping Deng; Ting Wong; Jim Y Wan; Anton Reiner
Journal:  Front Syst Neurosci       Date:  2014-10-15

Review 8.  The diagnostic value of saccades in movement disorder patients: a practical guide and review.

Authors:  Pichet Termsarasab; Thananan Thammongkolchai; Janet C Rucker; Steven J Frucht
Journal:  J Clin Mov Disord       Date:  2015-10-15

9.  Preliminary study of abnormalities in saccade dynamics in patients with hyperthyroidism with no pre-existing eye damage.

Authors:  Yan Sun; Xinhui Xie; Yongxia Xu; Chen Wang; Xiaoming Kong
Journal:  Exp Ther Med       Date:  2020-01-17       Impact factor: 2.447

10.  The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals.

Authors:  Filipa Júlio; Gina Caetano; Cristina Januário; Miguel Castelo-Branco
Journal:  Orphanet J Rare Dis       Date:  2019-11-08       Impact factor: 4.123
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.