Literature DB >> 21771607

Synthesis and antimicrobial studies of chalconyl pregnenolones.

Abid H Banday1, M Iqbal Zargar, Bashir A Ganaie.   

Abstract

An efficient and facile synthesis of 17-chalconyl derivatives of pregnenolone and their evaluation as antimicrobial agents against various microbial strains is reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding chalcone derivatives. The compounds 3a-3j showed significant antimicrobial activity against all microbial strains used for testing.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21771607     DOI： 10.1016/j.steroids.2011.07.001

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  2 in total

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  2 in total

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