OBJECTIVE: To assess the presence and identity of Bartonella species in a pool of human blood samples from DRC Congo. METHODS: Blood (±120μL) was collected anonymously from Congolese patients and placed on calibrated filter papers. Bartonella serology determination was performed using an indirect immunofluorescence assay (IFA) against six specific Bartonella antigens and Coxiella burnetii (C. burnetii) antigen. The end cut-off value for Bartonella sp. was a titre greater than 1:200. RESULTS: None of the patients was positive for Bartonella elizabethae, Bartonella vinsonii subsp. vinsonii or Bartonella vinsonii subsp. arupensis nor for C. burnetti, but 4.5% of the 155 samples were positive for either Bartonella henselae, Bartonella quintana, or Bartonella clarridgeiae. CONCLUSIONS: This preliminary study presents the first report of Bartonella species in the DR Congo and the first report of antibodies to Bartonella clarridgeiae in an African human population. Although few experimental trials have established the link between fleas and Bartonella transmission, the repeated detection of similar Bartonella species in fleas and humans in several countries suggests that Bartonellosis could be another flea-borne disease which specific reservoirs are still unknown.
OBJECTIVE: To assess the presence and identity of Bartonella species in a pool of human blood samples from DRC Congo. METHODS: Blood (±120μL) was collected anonymously from Congolese patients and placed on calibrated filter papers. Bartonella serology determination was performed using an indirect immunofluorescence assay (IFA) against six specific Bartonella antigens and Coxiella burnetii (C. burnetii) antigen. The end cut-off value for Bartonella sp. was a titre greater than 1:200. RESULTS: None of the patients was positive for Bartonella elizabethae, Bartonella vinsonii subsp. vinsonii or Bartonella vinsonii subsp. arupensis nor for C. burnetti, but 4.5% of the 155 samples were positive for either Bartonella henselae, Bartonella quintana, or Bartonella clarridgeiae. CONCLUSIONS: This preliminary study presents the first report of Bartonella species in the DR Congo and the first report of antibodies to Bartonella clarridgeiae in an African human population. Although few experimental trials have established the link between fleas and Bartonella transmission, the repeated detection of similar Bartonella species in fleas and humans in several countries suggests that Bartonellosis could be another flea-borne disease which specific reservoirs are still unknown.
Authors: Anne Laudisoit; Dadi Falay; Nicaise Amundala; Dudu Akaibe; Joëlle Goüy de Bellocq; Natalie Van Houtte; Matteo Breno; Erik Verheyen; Liesbeth Wilschut; Philippe Parola; Didier Raoult; Cristina Socolovschi Journal: Am J Trop Med Hyg Date: 2014-01-20 Impact factor: 2.345
Authors: Hamza Leulmi; Cristina Socolovschi; Anne Laudisoit; Gualbert Houemenou; Bernard Davoust; Idir Bitam; Didier Raoult; Philippe Parola Journal: PLoS Negl Trop Dis Date: 2014-10-09
Authors: Jo E B Halliday; Darryn L Knobel; Bernard Agwanda; Ying Bai; Robert F Breiman; Sarah Cleaveland; M Kariuki Njenga; Michael Kosoy Journal: PLoS Negl Trop Dis Date: 2015-03-17
Authors: Alexandra O Mannerings; Lynn M Osikowicz; Olivier Restif; Edward Nyarko; Richard Suu-Ire; Andrew A Cunningham; James L N Wood; Michael Y Kosoy Journal: Emerg Infect Dis Date: 2016-05 Impact factor: 6.883
Authors: Martin Wainaina; David Attuy Vey da Silva; Ian Dohoo; Anne Mayer-Scholl; Kristina Roesel; Dirk Hofreuter; Uwe Roesler; Johanna Lindahl; Bernard Bett; Sascha Al Dahouk Journal: PLoS Negl Trop Dis Date: 2022-01-24
Authors: Ying Bai; Modupe O V Osinubi; Lynn Osikowicz; Clifton McKee; Neil M Vora; Maria Rosales Rizzo; Sergio Recuenco; Lora Davis; Mike Niezgoda; Ajoke M Ehimiyein; Grace S N Kia; Akin Oyemakinde; Olufunmilayo Sanni Adeniyi; Yemi H Gbadegesin; Olugbon A Saliman; Abiodun Ogunniyi; Albert B Ogunkoya; Michael Y Kosoy Journal: Emerg Infect Dis Date: 2018-12 Impact factor: 6.883