Literature DB >> 21770434

Cytotoxic bipyridines from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6.

Peng Fu1, Shuxia Wang, Kui Hong, Xia Li, Peipei Liu, Yi Wang, Weiming Zhu.   

Abstract

Five new bipyridine alkaloids (1-5) and a new phenylpyridine alkaloid (6), which we name caerulomycins F-K, along with five known analogues (7-11), were isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. The structures of 1-6 were established on the basis of spectroscopic analyses and chemical methods. Compounds 1-10 showed cytotoxicity against the HL-60, K562, KB, and A549 cell lines, with IC₅₀ values of 0.26 to 15.7 μM. Compounds 7 and 8 also showed antimicrobial activities against Escherichia coli, Aerobacter aerogenes, Pseudomonas aeruginosa, and Candida albicans, with MIC values of 9.7 to 38.6 μM.

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Year:  2011        PMID： 21770434     DOI： 10.1021/np200258h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  23 in total

Review 1.  Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Authors:  Abraham J Waldman; Tai L Ng; Peng Wang; Emily P Balskus
Journal:  Chem Rev       Date:  2017-04-04       Impact factor: 60.622

2.  Nonsymmetrical Bis-Azine Biaryls from Chloroazines: A Strategy Using Phosphorus Ligand-Coupling.

Authors:  Benjamin T Boyle; Michael C Hilton; Andrew McNally
Journal:  J Am Chem Soc       Date:  2019-09-16       Impact factor: 15.419

3.  Diversity of actinobacteria in sediments of Qaidam Lake and Qinghai Lake, China.

Authors:  Jiang Wu; Zhong Peng; Tong-Wei Guan; Han Yang; Xiaqiong Tian
Journal:  Arch Microbiol       Date:  2021-03-22       Impact factor: 2.552

4.  Bioprospecting from marine sediments of New Brunswick, Canada: exploring the relationship between total bacterial diversity and actinobacteria diversity.

Authors:  Katherine Duncan; Bradley Haltli; Krista A Gill; Russell G Kerr
Journal:  Mar Drugs       Date:  2014-02-13       Impact factor: 5.118

5.  Cytotoxic and antimicrobial activities of secondary metabolites isolated from the deep-sea-derived Actinoalloteichus cyanogriseus 12A22.

Authors:  Xiaoying Zhang; Chunfeng Song; Yan Bai; Jiangchun Hu; Huaqi Pan
Journal:  3 Biotech       Date:  2021-05-21       Impact factor: 2.893

Review 6.  The secondary metabolites of rare actinomycetes: chemistry and bioactivity.

Authors:  Ting Ding; Luo-Jie Yang; Wei-Dong Zhang; Yun-Heng Shen
Journal:  RSC Adv       Date:  2019-07-16       Impact factor: 4.036

7.  Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora.

Authors:  Peng Fu; John B MacMillan
Journal:  J Nat Prod       Date:  2015-01-13       Impact factor: 4.050

Review 8.  Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes.

Authors:  Austin C Hachey; Dmytro Havrylyuk; Edith C Glazer
Journal:  Curr Opin Chem Biol       Date:  2021-03-30       Impact factor: 8.822

9.  Diketopiperazine derivatives from the marine-derived actinomycete Streptomyces sp. FXJ7.328.

Authors:  Pei Wang; Lijun Xi; Peipei Liu; Yi Wang; Wei Wang; Ying Huang; Weiming Zhu
Journal:  Mar Drugs       Date:  2013-03-28       Impact factor: 5.118

10.  Phylogenetic appraisal of antagonistic, slow growing actinomycetes isolated from hypersaline inland solar salterns at Sambhar salt Lake, India.

Authors:  Polpass Arul Jose; Solomon Robinson David Jebakumar
Journal:  Front Microbiol       Date:  2013-07-10       Impact factor: 5.640
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