| Literature DB >> 21770369 |
Jian Lin Li1, Sang Chul Han, Eun Sook Yoo, Sook Shin, Jongki Hong, Zheng Cui, Huayue Li, Jee H Jung.
Abstract
Four new amino acid derivatives, herdmanines A-D (1-4), were isolated from the marine ascidian Herdmania momus. Herdmanines A-C contain the unusual D-form of arginine. Compounds 3 and 4 had a moderate suppressive effect on the production of NO, with IC₅₀ values of 96 and 9 μM, respectively. These compounds were found to inhibit the mRNA expression of iNOS. The inhibitory activities on the production and mRNA expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 were evaluated.Entities:
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Year: 2011 PMID： 21770369 DOI： 10.1021/np200397g
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050