Literature DB >> 21770036

Oxygen-dependent delayed fluorescence measured in skin after topical application of 5-aminolevulinic acid.

Floor A Harms1, Wadim M I de Boon, Gianmarco M Balestra, Sander I A Bodmer, Tanja Johannes, Robert J Stolker, Egbert G Mik.   

Abstract

Mitochondrial oxygen tension can be measured in vivo by means of oxygen-dependent quenching of delayed fluorescence of protoporphyrin IX (PpIX). Here we demonstrate that delayed fluorescence is readily observed from skin in rat and man after topical application of the PpIX precursor 5-aminolevulinic acid (ALA). Delayed fluorescence lifetimes respond to changes in inspired oxygen fraction and blood supply. The signals contain lifetime distributions and the fitting of rectangular distributions to the data appears more adequate than mono-exponential fitting. The use of topically applied ALA for delayed fluorescence lifetime measurements might pave the way for clinical use of this technique.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21770036     DOI： 10.1002/jbio.201100040

Source DB:  PubMed          Journal:  J Biophotonics        ISSN： 1864-063X            Impact factor:   3.207


  10 in total

Review 1.  Optical probes and techniques for O2 measurement in live cells and tissue.

Authors:  Ruslan I Dmitriev; Dmitri B Papkovsky
Journal:  Cell Mol Life Sci       Date:  2012-01-17       Impact factor: 9.261

2.  Cutaneous mitochondrial respirometry: non-invasive monitoring of mitochondrial function.

Authors:  Floor A Harms; Sander I A Bodmer; Nicolaas J H Raat; Egbert G Mik
Journal:  J Clin Monit Comput       Date:  2014-11-12       Impact factor: 2.502

3.  Non-invasive monitoring of mitochondrial oxygenation and respiration in critical illness using a novel technique.

Authors:  Floor A Harms; Sander I A Bodmer; Nicolaas J H Raat; Egbert G Mik
Journal:  Crit Care       Date:  2015-09-22       Impact factor: 9.097

4.  Pulse frequency dependency of photobiomodulation on the bioenergetic functions of human dental pulp stem cells.

Authors:  Hong Bae Kim; Ku Youn Baik; Pill-Hoon Choung; Jong Hoon Chung
Journal:  Sci Rep       Date:  2017-11-21       Impact factor: 4.379

5.  Study protocol and pilot results of an observational cohort study evaluating effect of red blood cell transfusion on oxygenation and mitochondrial oxygen tension in critically ill patients with anaemia: the INsufficient Oxygenation in the Intensive Care Unit (INOX ICU-2) study.

Authors:  Meryem Baysan; Mendi S Arbous; Egbert G Mik; Nicole P Juffermans; Johanna G van der Bom
Journal:  BMJ Open       Date:  2020-05-17       Impact factor: 2.692

6.  Evaluation of endoscopic visible light spectroscopy: comparison with microvascular oxygen tension measurements in a porcine model.

Authors:  Rinse Ubbink; Louisa J D van Dijk; Desirée van Noord; Tanja Johannes; Patricia A C Specht; Marco J Bruno; Egbert G Mik
Journal:  J Transl Med       Date:  2019-02-28       Impact factor: 5.531

7.  Oxygen-dependent delayed fluorescence of protoporphyrin IX measured in the stomach and duodenum during upper gastrointestinal endoscopy.

Authors:  Louisa J D van Dijk; Rinse Ubbink; Luke G Terlouw; Desirée van Noord; Egbert G Mik; Marco J Bruno
Journal:  J Biophotonics       Date:  2019-06-20       Impact factor: 3.207

8.  Relationship between delayed luminescence emission and mitochondrial status in Saccharomyces cerevisiae.

Authors:  Miao Tian; Qing Li; Yang Liu; Peng Zheng; Danyu Li; Yanpeng Zhao; Bing Wang; Chenhao Li; Jing Wang; Peng Gao; Qing Tang; Xiaochun Zhang; Hong Wu
Journal:  Sci Rep       Date:  2022-01-10       Impact factor: 4.379

9.  In Vivo and Ex Vivo Mitochondrial Function in COVID-19 Patients on the Intensive Care Unit.

Authors:  Lucia W J M Streng; Calvin J de Wijs; Nicolaas J H Raat; Patricia A C Specht; Dimitri Sneiders; Mariëlle van der Kaaij; Henrik Endeman; Egbert G Mik; Floor A Harms
Journal:  Biomedicines       Date:  2022-07-20

10.  Cutaneous Respirometry as Novel Technique to Monitor Mitochondrial Function: A Feasibility Study in Healthy Volunteers.

Authors:  Floor Anneleen Harms; Robert Jan Stolker; Egbert Gezinus Mik
Journal:  PLoS One       Date:  2016-07-25       Impact factor: 3.240
  10 in total

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