Literature DB >> 2176936

Lack of antinociceptive activity of sumatriptan in rodents.

M Skingle1, P J Birch, G E Leighton, P P Humphrey.   

Abstract

The present study attempts to determine whether the novel anti-migraine drug sumatriptan has antinociceptive activity in rodents. Sumatriptan had little or no antinociceptive activity against a range of noxious stimuli and we therefore conclude that it is unlikely that the beneficial effects of the drug in treating migraine are due to a non-specific analgesic action.

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Year:  1990        PMID: 2176936     DOI: 10.1046/j.1468-2982.1990.1005207.x

Source DB:  PubMed          Journal:  Cephalalgia        ISSN: 0333-1024            Impact factor:   6.292


  12 in total

1.  The antimigraine 5-HT 1B/1D receptor agonists, sumatriptan, zolmitriptan and dihydroergotamine, attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain.

Authors:  Valérie Kayser; Bertrand Aubel; Michel Hamon; Sylvie Bourgoin
Journal:  Br J Pharmacol       Date:  2002-12       Impact factor: 8.739

2.  Role of 5-HT(1) receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn.

Authors:  Hyo-Jin Jeong; Vanessa A Mitchell; Christopher W Vaughan
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

3.  Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission.

Authors:  Bryony L Winters; Hyo-Jin Jeong; Christopher W Vaughan
Journal:  Br J Pharmacol       Date:  2020-07-08       Impact factor: 8.739

Review 4.  Where do triptans act in the treatment of migraine?

Authors:  Andrew H Ahn; Allan I Basbaum
Journal:  Pain       Date:  2005-05       Impact factor: 6.961

5.  Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain.

Authors:  Andrew H Ahn; Allan I Basbaum
Journal:  J Neurosci       Date:  2006-08-09       Impact factor: 6.167

6.  Effects of a selective 5-HT(1B/1D) receptor agonist on spinal and trigeminal reflexes in the anaesthetized rabbit.

Authors:  S Jenkins; B Richardson; R W Clarke
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739

Review 7.  Does sumatriptan cross the blood-brain barrier in animals and man?

Authors:  Peer Carsten Tfelt-Hansen
Journal:  J Headache Pain       Date:  2009-12-10       Impact factor: 7.277

Review 8.  Animal migraine models for drug development: status and future perspectives.

Authors:  Inger Jansen-Olesen; Peer Tfelt-Hansen; Jes Olesen
Journal:  CNS Drugs       Date:  2013-12       Impact factor: 5.749

Review 9.  Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache.

Authors:  K L Dechant; S P Clissold
Journal:  Drugs       Date:  1992-05       Impact factor: 9.546

Review 10.  Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache.

Authors:  G L Plosker; D McTavish
Journal:  Drugs       Date:  1994-04       Impact factor: 9.546

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