Literature DB >> 21769068

Prognosis in intracerebral hemorrhage.

Kenneth M Crandall1, Natalia S Rost, Kevin N Sheth.   

Abstract

Intracerebral hemorrhage (ICH) is the most devastating type of stroke with the greatest mortality rate. Unfortunately there are no clinically proven therapies, and treatment is typically supportive. Given the poor prognosis, many families are faced with the decision to limit or withdraw care from those who have had an ICH. Many clinical grading systems have been developed to help stratify patients with ICH and aid in predicting prognosis. The ICH scale was the first to be developed to predict 30-day mortality and has been validated by different cohorts around the world. Since its inception in 2001, numerous other scales have been developed to predict mortality, and more importantly, functional outcome. However, in the development of these scales, patients who had care withdrawn were included in the analysis. It has been shown that the concept of poor prognosis leads to do-not-resuscitate orders, less invasive care, and eventually death. Most of these patients have care withdrawn within the first two hospital days, despite evidence to suggest early interventions may improve outcomes. As a result, the most recent guidelines suggest waiting more than 24 hours before deciding to withdraw care. The use and interpretation of these ever-advancing scales may allow physicians to better predict outcome and assist families in making important care-related decisions.

Entities:  

Mesh:

Year:  2011        PMID: 21769068

Source DB:  PubMed          Journal:  Rev Neurol Dis        ISSN: 1545-2913


  11 in total

1.  Genetic deletion of the prostaglandin E2 E prostanoid receptor subtype 3 improves anatomical and functional outcomes after intracerebral hemorrhage.

Authors:  Jenna L Leclerc; Andrew S Lampert; Matthew A Diller; Sylvain Doré
Journal:  Eur J Neurosci       Date:  2015-05       Impact factor: 3.386

2.  For Primary Prevention, Should All Moderate- to High-Risk Patients Be Considered Candidates for Acetylsalicylic Acid?

Authors: 
Journal:  Can J Hosp Pharm       Date:  2020-02-01

3.  Up-regulation of VCAM1 Relates to Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats.

Authors:  Dongmei Zhang; Damin Yuan; Jianhong Shen; Yaohua Yan; Chen Gong; Jun Gu; Huaqing Xue; Yuhang Qian; Weidong Zhang; Xiaojuan He; Li Yao; Yuhong Ji; Aiguo Shen
Journal:  Neurochem Res       Date:  2015-04-14       Impact factor: 3.996

4.  Up-regulation of NFATc4 involves in neuronal apoptosis following intracerebral hemorrhage.

Authors:  Lei Li; Kaifu Ke; Xiang Tan; Wei Xu; Jiabing Shen; Tingting Zhai; Ling Xu; Ying Rui; Heyi Zheng; Peipei Zhai; Jianghua Zhao; Maohong Cao
Journal:  Cell Mol Neurobiol       Date:  2013-07-14       Impact factor: 5.046

5.  CDK5 contributes to neuronal apoptosis via promoting MEF2D phosphorylation in rat model of intracerebral hemorrhage.

Authors:  Kaifu Ke; Jiabing Shen; Yan Song; Maohong Cao; Hongjian Lu; Chun Liu; Jianhong Shen; Aihong Li; Jie Huang; Haidan Ni; Xiaomei Chen; Yonghua Liu
Journal:  J Mol Neurosci       Date:  2014-11-23       Impact factor: 3.444

6.  OTUB1 attenuates neuronal apoptosis after intracerebral hemorrhage.

Authors:  Lili Xie; Aihong Li; Jiabing Shen; Maohong Cao; Xiaojin Ning; Debin Yuan; Yuteng Ji; Hongmei Wang; Kaifu Ke
Journal:  Mol Cell Biochem       Date:  2016-09-15       Impact factor: 3.396

7.  Up-Regulation of KPNB1 Involves in Neuronal Apoptosis Following Intracerebral Hemorrhage in Adult Rats.

Authors:  Aihua Dai; Xiaorong Liu; Yu Zhang; Lijian Han; Liang Zhu; Haidan Ni; Rongrong Chen; Maohong Cao
Journal:  Neurochem Res       Date:  2015-08-25       Impact factor: 3.996

8.  Epidemiological and clinical characteristics of 266 cases of intracerebral hemorrhage in Hangzhou, China.

Authors:  Yun-zhen Hu; Jian-wen Wang; Ben-yan Luo
Journal:  J Zhejiang Univ Sci B       Date:  2013-06       Impact factor: 3.066

9.  Prostaglandin E2 EP2 receptor deletion attenuates intracerebral hemorrhage-induced brain injury and improves functional recovery.

Authors:  Jenna L Leclerc; Andrew S Lampert; Matthew A Diller; Joshua B Immergluck; Sylvain Doré
Journal:  ASN Neuro       Date:  2015-04-13       Impact factor: 4.146

10.  Prognostic Factors of Clinical Outcomes in Patients with Spontaneous Thalamic Hemorrhage.

Authors:  Sang-Hoon Lee; Kyung-Jae Park; Shin-Hyuk Kang; Yong-Gu Jung; Jung-Yul Park; Dong-Hyuk Park
Journal:  Med Sci Monit       Date:  2015-09-05
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