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Literature DB >> 21767669

Pyridoxal phosphate: biosynthesis and catabolism.

Tathagata Mukherjee¹, Jeremiah Hanes, Ivo Tews, Steven E Ealick, Tadhg P Begley.

Abstract

Vitamin B(6) is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment. It is one of the few cofactors whose catabolic pathway has been comprehensively characterized. It is also known to function as a singlet oxygen scavenger and has protective effects against oxidative stress in fungi. Enzymes utilizing vitamin B(6) are important targets for therapeutic agents. This review provides a concise overview of the mechanistic enzymology of vitamin B(6) biosynthesis and catabolism. This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology.

Entities: Chemical

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Year: 2011 PMID： 21767669 DOI： 10.1016/j.bbapap.2011.06.018

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

35 in total

1. Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.

Authors: Sara Sanders; Ryan J Vierling; David Bartee; Alicia A DeColli; Mackenzie J Harrison; Joseph L Aklinski; Andrew T Koppisch; Caren L Freel Meyers
Journal: ACS Infect Dis Date: 2017-06-21 Impact factor: 5.084

2. X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.

Authors: Percival Yang-Ting Chen; Alicia A DeColli; Caren L Freel Meyers; Catherine L Drennan
Journal: J Biol Chem Date: 2019-06-25 Impact factor: 5.157

3. Genome Analysis of Endomicrobium proavitum Suggests Loss and Gain of Relevant Functions during the Evolution of Intracellular Symbionts.

Authors: Hao Zheng; Carsten Dietrich; Andreas Brune
Journal: Appl Environ Microbiol Date: 2017-08-17 Impact factor: 4.792

10. The vitamin B₆ biosynthesis pathway in Streptococcus pneumoniae is controlled by pyridoxal 5'-phosphate and the transcription factor PdxR and has an impact on ear infection.

Authors: Samir El Qaidi; Jun Yang; Jing-Ren Zhang; Dennis W Metzger; Guangchun Bai
Journal: J Bacteriol Date: 2013-03-08 Impact factor: 3.490

Pyridoxal phosphate: biosynthesis and catabolism.

1. Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.

2. X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.

3. Genome Analysis of Endomicrobium proavitum Suggests Loss and Gain of Relevant Functions during the Evolution of Intracellular Symbionts.

Review 4. Monooxygenation of aromatic compounds by flavin-dependent monooxygenases.

5. Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network.

6. Conformational dynamics of 1-deoxy-d-xylulose 5-phosphate synthase on ligand binding revealed by H/D exchange MS.

Review 7. Utilization of glyphosate as phosphate source: biochemistry and genetics of bacterial carbon-phosphorus lyase.

8. An Unexpected Role for the Periplasmic Phosphatase PhoN in the Salvage of B₆ Vitamers in Salmonella enterica.

Review 9. Intracellular trafficking of the pyridoxal cofactor. Implications for health and metabolic disease.

10. The vitamin B₆ biosynthesis pathway in Streptococcus pneumoniae is controlled by pyridoxal 5'-phosphate and the transcription factor PdxR and has an impact on ear infection.