| Literature DB >> 21764589 |
Shuhei Murayama1, Yasufumi Imae, Kentaro Takada, Jo Kikuchi, Yoichi Nakao, Rob W M van Soest, Shigeru Okada, Shigeki Matsunaga.
Abstract
Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC(50) value of 8 μg/mL each.Entities:
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Year: 2011 PMID： 21764589 DOI： 10.1016/j.bmc.2011.06.052
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641