| Literature DB >> 21764580 |
Gabriella Gentile1, Giovanni Bernasconi, Alfonso Pozzan, Giancarlo Merlo, Paola Marzorati, Paul Bamborough, Benjamin Bax, Angela Bridges, Caroline Brough, Paul Carter, Geoffrey Cutler, Margarete Neu, Mia Takada.
Abstract
The discovery of a novel series of 2-(4-pyridyl)thienopyridinone GSK-3β inhibitors is reported. X-ray crystallography reveals its binding mode and enables rationalization of the SAR. The initial optimization of the template for improved cellular activity and predicted CNS penetration is also presented.Entities:
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Year: 2011 PMID： 21764580 DOI： 10.1016/j.bmcl.2011.06.050
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823