Potential trehalase inhibitors: syntheses of trehazolin and its analogues.

Trehazolin is a natural pseudodisaccharide obtained from Micromonospora strain SANK 62390 and Amycolaptosis trehalostatica, and later on it was found to be widely distributed in microorganisms, insects, plants, and animals. It has received much attention because of its importance as an inhibitor of the enzyme trehalase. This article is focused on the synthesis of natural trehazolin and its analogues, with details of the synthetic methods. Sufficient information is given to permit the selection of a suitable synthetic route for trehazolin and/or its analogues. Various approaches are provided for the synthesis of natural trehazolin and its analogues in a way that enables the researcher to decide whether to use a certain procedure, modify it, or propose a new synthetic methodology.