| Literature DB >> 21763416 |
Raphaële Castagné1, Tanja Zeller, Maxime Rotival, Silke Szymczak, Vinh Truong, Arne Schillert, David-Alexandre Trégouët, Thomas Münzel, Andreas Ziegler, François Cambien, Stefan Blankenberg, Laurence Tiret.
Abstract
In humans, the fraction of X-linked genes with higher expression in females has been estimated to be 5% from microarray studies, a proportion lower than the 25% of genes thought to escape X inactivation. We analyzed 715 X-linked transcripts in circulating monocytes from 1,467 subjects and found an excess of female-biased transcripts on the X compared to autosomes (9.4% vs 5.5%, p<2×10(-5)). Among the genes not previously known to escape inactivation, the most significant one was EFHC2 whose 20% of variability was explained by sex. We also investigated cis expression quantitative trait loci (eQTLs) by analyzing 15,703 X-linked SNPs. The frequency and magnitude of X-linked cis eQTLs were quite similar in males and females. Few genes exhibited a stronger genetic effect in females than in males (ARSD, DCX, POLA1 and ITM2A). These genes would deserve further investigation since they may contribute to sex pathophysiological differences. Copyright ÂEntities:
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Year: 2011 PMID： 21763416 DOI： 10.1016/j.ygeno.2011.06.009
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736