| Literature DB >> 21762720 |
Julio Vera1, Katja Rateitschak, Falko Lange, Christina Kossow, Olaf Wolkenhauer, Robert Jaster.
Abstract
Originally implicated in the regulation of survival, proliferation and differentiation of haematopoietic cells, the JAK-STAT pathway has also been linked to developmental processes, growth control and maintenance of homeostasis in a variety of other cells and tissues. Although it remains a complex system, its relative simplicity and the availability of molecular data makes it particularly attractive for modelling approaches. In this review, we will focus on JAK-STAT signalling in the context of cancer and present efforts to investigate signalling dynamics with the help of mathematical models. We describe the modelling workflow that realises a systems biology approach and give an example for interferon-γ signalling in pancreatic stellate cells.Entities:
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Year: 2011 PMID： 21762720 DOI： 10.1016/j.pbiomolbio.2011.06.013
Source DB: PubMed Journal: Prog Biophys Mol Biol ISSN： 0079-6107 Impact factor: 3.667