Literature DB >> 2176200

A structural protein encoded by the 5' region of the hepatitis C virus genome efficiently detects viral infection.

N Kato1, M Hijikata, Y Ootsuyama, M Nakagawa, S Ohkoshi, K Shimotohno.   

Abstract

A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non-structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.

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Year:  1990        PMID： 2176200      PMCID： PMC5917981          DOI： 10.1111/j.1349-7006.1990.tb02518.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  9 in total

1.  Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.

Authors:  Q L Choo; G Kuo; A J Weiner; L R Overby; D W Bradley; M Houghton
Journal:  Science       Date:  1989-04-21       Impact factor: 47.728

2.  Detection of serum hepatitis C virus RNA.

Authors:  S Kaneko; M Unoura; K Kobayashi; K Kuno; S Murakami; N Hattori
Journal:  Lancet       Date:  1990-04-21       Impact factor: 79.321

3.  Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis.

Authors:  J Bruix; J M Barrera; X Calvet; G Ercilla; J Costa; J M Sanchez-Tapias; M Ventura; M Vall; M Bruguera; C Bru
Journal:  Lancet       Date:  1989-10-28       Impact factor: 79.321

4.  Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma.

Authors:  M Colombo; G Kuo; Q L Choo; M F Donato; E Del Ninno; M A Tommasini; N Dioguardi; M Houghton
Journal:  Lancet       Date:  1989-10-28       Impact factor: 79.321

5.  Identification of new gene products coded from X regions of human T-cell leukemia viruses.

Authors:  K Shimotohno; M Miwa; D J Slamon; I S Chen; H Hoshino; M Takano; M Fujino; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

6.  The 5'-terminal sequence of the hepatitis C virus genome.

Authors:  H Okamoto; S Okada; Y Sugiyama; S Yotsumoto; T Tanaka; H Yoshizawa; F Tsuda; Y Miyakawa; M Mayumi
Journal:  Jpn J Exp Med       Date:  1990-06

7.  Prevalence of antibody against non-A, non-B hepatitis virus in Japanese patients with hepatocellular carcinoma.

Authors:  S Ohkoshi; H Kojima; H Tawaraya; T Miyajima; T Kamimura; H Asakura; A Satoh; S Hirose; M Hijikata; N Kato
Journal:  Jpn J Cancer Res       Date:  1990 Jun-Jul

8.  An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis.

Authors:  G Kuo; Q L Choo; H J Alter; G L Gitnick; A G Redeker; R H Purcell; T Miyamura; J L Dienstag; M J Alter; C E Stevens
Journal:  Science       Date:  1989-04-21       Impact factor: 47.728

9.  Detection of hepatitis C virus RNA in sera and liver tissues of non-A, non-B hepatitis patients using the polymerase chain reaction.

Authors:  S Ohkoshi; N Kato; T Kinoshita; M Hijikata; Y Ohtsuyama; N Okazaki; H Ohkura; S Hirohashi; A Honma; T Ozaki
Journal:  Jpn J Cancer Res       Date:  1990-09
  9 in total
  2 in total

1.  Sites of vulnerability in HCV E1E2 identified by comprehensive functional screening.

Authors:  Jennifer M Pfaff-Kilgore; Edgar Davidson; Kathryn Kadash-Edmondson; Mayda Hernandez; Erin Rosenberg; Ross Chambers; Matteo Castelli; Nicola Clementi; Nicasio Mancini; Justin R Bailey; James E Crowe; Mansun Law; Benjamin J Doranz
Journal:  Cell Rep       Date:  2022-05-24       Impact factor: 9.995

2.  Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus.

Authors:  N Kato; H Sekiya; Y Ootsuyama; T Nakazawa; M Hijikata; S Ohkoshi; K Shimotohno
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103
  2 in total

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