Literature DB >> 21761060

A new tool to assess ceramide bioactivity: 6-bromo-7-hydroxycoumarinyl-caged ceramide.

Young Ah Kim1, Daniel M Carter Ramirez, Willard J Costain, Linda J Johnston, Robert Bittman.   

Abstract

The bioactivity of natural, long-chain ceramides has until now been studied after its delivery to cells in organic solvent mixtures containing dodecane. We have synthesized ceramides conjugated to a (6-bromo-7-hydroxycoumarin-4-yl)methyl group. The photocaged ceramide is efficiently released with 350 nm light in aqueous solution at neutral pH, thus providing a promising new tool to study ceramide's properties.

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Year:  2011        PMID： 21761060     DOI： 10.1039/c1cc12345a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Spacer-Mediated Control of Coumarin Uncaging for Photocaged Thymidine.

Authors:  Shengzhuang Tang; Jayme Cannon; Kelly Yang; Matthew F Krummel; James R Baker; Seok Ki Choi
Journal:  J Org Chem       Date:  2020-02-05       Impact factor: 4.354

2.  Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

Authors:  Roy Weinstain; Tomáš Slanina; Dnyaneshwar Kand; Petr Klán
Journal:  Chem Rev       Date:  2020-10-30       Impact factor: 60.622

3.  Synthesis and photochemical properties of PEGylated coumarin-caged ceramides for cell studies.

Authors:  Young Ah Kim; Jenna Day; Carol Ann Lirette; Willard J Costain; Linda J Johnston; Robert Bittman
Journal:  Chem Phys Lipids       Date:  2015-07-19       Impact factor: 3.329

4.  Photouncaging of ceramides promotes reorganization of liquid-ordered domains in supported lipid bilayers.

Authors:  Daniel M Carter Ramirez; Spencer P Pitre; Young Ah Kim; Robert Bittman; Linda J Johnston
Journal:  Langmuir       Date:  2013-02-25       Impact factor: 3.882

5.  Lipid Phase Separation and Protein-Ganglioside Clustering in Supported Bilayers Are Induced by Photorelease of Ceramide.

Authors:  Daniel M Carter Ramirez; Young Ah Kim; Robert Bittman; Linda J Johnston
Journal:  Soft Matter       Date:  2013-05-21       Impact factor: 3.679

6.  Traceless synthesis of ceramides in living cells reveals saturation-dependent apoptotic effects.

Authors:  Andrew K Rudd; Neal K Devaraj
Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-02       Impact factor: 11.205

7.  Control of an Unusual Photo-Claisen Rearrangement in Coumarin Caged Tamoxifen through an Extended Spacer.

Authors:  Pamela T Wong; Edward W Roberts; Shengzhuang Tang; Jhindan Mukherjee; Jayme Cannon; Alyssa J Nip; Kaitlin Corbin; Matthew F Krummel; Seok Ki Choi
Journal:  ACS Chem Biol       Date:  2017-02-17       Impact factor: 5.100

8.  Glucosylceramide acyl chain length is sensed by the glycolipid transfer protein.

Authors:  Anders P E Backman; Josefin Halin; Henrik Nurmi; Anna Möuts; Matti A Kjellberg; Peter Mattjus
Journal:  PLoS One       Date:  2018-12-14       Impact factor: 3.240

Review 9.  Caged lipids for subcellular manipulation.

Authors:  Scotland Farley; Aurélien Laguerre; Carsten Schultz
Journal:  Curr Opin Chem Biol       Date:  2021-06-10       Impact factor: 8.822
  9 in total

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