OBJECTIVE:Dietary carotenoids (lutein, lycopene and β-carotene) may be important in preventing or ameliorating prematurity complications. Little is known about carotenoid status or effects of supplementation. STUDY DESIGN: This randomized controlled multicenter trial compared plasma carotenoid levels among preterm infants (n=203, <33 weeks gestational age) feddiets with and without added lutein, lycopene and β-carotene with human milk (HM)-fed term infants. We assessed safety and health. RESULT: Plasma carotenoid levels were higher in the supplemented group at all time points (P<0.0001) and were similar to those of term HM-fed infants. Supplemented infants had lower plasma C-reactive protein (P<0.001). Plasma lutein levels correlated with the full field electroretinogram-saturated response amplitude in rod photoreceptors (r=0.361, P=0.05). The supplemented group also showed greater rod photoreceptor sensitivity (least squares means 6.1 vs 4.1; P<0.05). CONCLUSION:Carotenoid supplementation for preterm infants raises plasma concentrations to those observed in HM-fed term infants. Carotenoid supplementation may decrease inflammation. Our results point to protective effects of lutein on preterm retina health and maturation.
RCT Entities:
OBJECTIVE: Dietary carotenoids (lutein, lycopene and β-carotene) may be important in preventing or ameliorating prematurity complications. Little is known about carotenoid status or effects of supplementation. STUDY DESIGN: This randomized controlled multicenter trial compared plasma carotenoid levels among preterm infants (n=203, <33 weeks gestational age) fed diets with and without added lutein, lycopene and β-carotene with human milk (HM)-fed term infants. We assessed safety and health. RESULT: Plasma carotenoid levels were higher in the supplemented group at all time points (P<0.0001) and were similar to those of term HM-fed infants. Supplemented infants had lower plasma C-reactive protein (P<0.001). Plasma lutein levels correlated with the full field electroretinogram-saturated response amplitude in rod photoreceptors (r=0.361, P=0.05). The supplemented group also showed greater rod photoreceptor sensitivity (least squares means 6.1 vs 4.1; P<0.05). CONCLUSION:Carotenoid supplementation for preterm infants raises plasma concentrations to those observed in HM-fed term infants. Carotenoid supplementation may decrease inflammation. Our results point to protective effects of lutein on preterm retina health and maturation.
Authors: Paul S Bernstein; Mohsen Sharifzadeh; Aihua Liu; Igor Ermakov; Kelly Nelson; Xiaoming Sheng; Cynthia Panish; Bonnie Carlstrom; Robert O Hoffman; Werner Gellermann Journal: Invest Ophthalmol Vis Sci Date: 2013-06-10 Impact factor: 4.799
Authors: Lewis P Rubin; A Catharine Ross; Charles B Stephensen; Torsten Bohn; Sherry A Tanumihardjo Journal: Adv Nutr Date: 2017-03-15 Impact factor: 8.701
Authors: Gary M Chan; Melissa M Chan; Werner Gellermann; Igor Ermakov; Maia Ermakova; Prakash Bhosale; Paul Bernstein; Carrie Rau Journal: J Pediatr Gastroenterol Nutr Date: 2013-05 Impact factor: 2.839
Authors: M Ortiz-Espejo; M Gil-Campos; M D Mesa; C E García-Rodríguez; M C Muñoz-Villanueva; J L Pérez-Navero Journal: Eur J Nutr Date: 2013-08-08 Impact factor: 5.614