Literature DB >> 21760583

Drugs: a tangled web of targets.

Lauren Gravitz.   

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Year:  2011        PMID： 21760583     DOI： 10.1038/475S9a

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


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  5 in total

1.  Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity.

Authors:  David X Medina; Antonella Caccamo; Salvatore Oddo
Journal:  Brain Pathol       Date:  2011-03       Impact factor: 6.508

Review 2.  Alzheimer's disease: clinical trials and drug development.

Authors:  Francesca Mangialasche; Alina Solomon; Bengt Winblad; Patrizia Mecocci; Miia Kivipelto
Journal:  Lancet Neurol       Date:  2010-07       Impact factor: 44.182

3.  Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift.

Authors:  Todd E Golde; Lon S Schneider; Edward H Koo
Journal:  Neuron       Date:  2011-01-27       Impact factor: 17.173

4.  11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study.

Authors:  Juha O Rinne; David J Brooks; Martin N Rossor; Nick C Fox; Roger Bullock; William E Klunk; Chester A Mathis; Kaj Blennow; Jerome Barakos; Aren A Okello; Sofia Rodriguez Martinez de Liano; Enchi Liu; Martin Koller; Keith M Gregg; Dale Schenk; Ronald Black; Michael Grundman
Journal:  Lancet Neurol       Date:  2010-02-26       Impact factor: 44.182

Review 5.  Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.

Authors:  Michael P Mazanetz; Peter M Fischer
Journal:  Nat Rev Drug Discov       Date:  2007-06       Impact factor: 84.694
  5 in total
  29 in total

1.  Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice.

Authors:  Takashi Mori; Naoki Koyama; Tatsuya Segawa; Masahiro Maeda; Nobuhiro Maruyama; Noriaki Kinoshita; Huayan Hou; Jun Tan; Terrence Town
Journal:  J Biol Chem       Date:  2014-08-25       Impact factor: 5.157

2.  The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.

Authors:  Bin Zhang; Jenna Carroll; John Q Trojanowski; Yuemang Yao; Michiyo Iba; Justin S Potuzak; Anne-Marie L Hogan; Sharon X Xie; Carlo Ballatore; Amos B Smith; Virginia M-Y Lee; Kurt R Brunden
Journal:  J Neurosci       Date:  2012-03-14       Impact factor: 6.167

3.  Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease.

Authors:  Xueli Zhang; Yanli Tian; Zeng Li; Xiaoyu Tian; Hongbin Sun; Hong Liu; Anna Moore; Chongzhao Ran
Journal:  J Am Chem Soc       Date:  2013-10-25       Impact factor: 15.419

Review 4.  Is amyloid binding alcohol dehydrogenase a drug target for treating Alzheimer's disease?

Authors:  Eva Borger; Laura Aitken; Heng Du; Wenshen Zhang; Frank J Gunn-Moore; Shirley Shi Du Yan
Journal:  Curr Alzheimer Res       Date:  2013-01       Impact factor: 3.498

5.  Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load chronically, as demonstrated in vivo.

Authors:  M S Bobola; L Chen; C K Ezeokeke; T A Olmstead; C Nguyen; A Sahota; R G Williams; P D Mourad
Journal:  Brain Stimul       Date:  2020-04-01       Impact factor: 8.955

6.  Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.

Authors:  Mizuho Sato; Kazuma Murakami; Mayumi Uno; Yu Nakagawa; Sumie Katayama; Ken-ichi Akagi; Yuichi Masuda; Kiyonori Takegoshi; Kazuhiro Irie
Journal:  J Biol Chem       Date:  2013-06-21       Impact factor: 5.157

7.  PharmGKB summary: methylene blue pathway.

Authors:  Ellen M McDonagh; José M Bautista; Ilan Youngster; Russ B Altman; Teri E Klein
Journal:  Pharmacogenet Genomics       Date:  2013-09       Impact factor: 2.089

Review 8.  Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration.

Authors:  Khalid Bashir Dar; Aashiq Hussain Bhat; Shajrul Amin; Bilal Ahmad Reshi; Mohammad Afzal Zargar; Akbar Masood; Showkat Ahmad Ganie
Journal:  Cell Mol Neurobiol       Date:  2019-10-04       Impact factor: 5.046

Review 9.  Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots.

Authors:  Shao-Hua Yang; Wenjun Li; Nathalie Sumien; Michael Forster; James W Simpkins; Ran Liu
Journal:  Prog Neurobiol       Date:  2015-11-18       Impact factor: 11.685

10.  Repetitive Transcranial Magnetic Stimulation Improves Mild Cognitive Impairment Associated with Alzheimer's Disease in Mice by Modulating the miR-567/NEUROD2/PSD95 Axis.

Authors:  Yongfeng Pang; Mingfei Shi
Journal:  Neuropsychiatr Dis Treat       Date:  2021-07-02       Impact factor: 2.570
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