OBJECTIVE: To compare the clinical features, management, and outcome of critically ill children with H1N1 to children with seasonal influenza from the previous three influenza seasons. DESIGN: The overall number of hospitalizations and the proportion cared for in the pediatric intensive care unit during the H1N1 epidemic period and the three previous influenza seasons (2007-2009) were determined. Medical records of patients admitted to the pediatric intensive care unit with H1N1 and seasonal influenza infection were reviewed. SETTING: Cincinnati Children's Hospital Medical Center, a large, 523-bed hospital located in Cincinnati. PATIENTS: Hospitalized children with laboratory-confirmed seasonal or H1N1 infection. MEASUREMENTS: Study variables included demographic data (age, gender), clinical factors (weight, Pediatric Risk of Mortality III scores, presenting signs and symptoms, comorbid conditions), management (length of mechanical ventilation, other treatments, including high-frequency oscillatory ventilatory support, inhaled nitric oxide, or extracorporeal membrane oxygenation), and outcome (overall and pediatric intensive care unit length of stay and mortality). MAIN RESULTS: Overall, 312 children were hospitalized with H1N1 and 222 with seasonal influenza from the three previous seasons. Children with H1N1 infection were significantly less likely to require pediatric intensive care unit care compared to children with seasonal influenza infection (14% vs. 24%, p = .02). Compared to children with seasonal influenza, children in the pediatric intensive care unit with H1N1 were older (median age in months 107 vs. 68, p = .05) and significantly more likely to have comorbid conditions (64% vs. 40%, p = .03), especially respiratory conditions. While there were no significant differences in severity of illness by Pediatric Risk of Mortality III scores or pediatric intensive care unit length of stay, children with H1N1 were significantly less likely to have acute respiratory failure (p = .04) or die compared to children with seasonal influenza infection (p = .03). CONCLUSIONS: In contrast to other studies, we found that critically ill children with H1N1 had a significantly lower morbidity and mortality compared to children with seasonal influenza.
OBJECTIVE: To compare the clinical features, management, and outcome of critically ill children with H1N1 to children with seasonal influenza from the previous three influenza seasons. DESIGN: The overall number of hospitalizations and the proportion cared for in the pediatric intensive care unit during the H1N1 epidemic period and the three previous influenza seasons (2007-2009) were determined. Medical records of patients admitted to the pediatric intensive care unit with H1N1 and seasonal influenza infection were reviewed. SETTING: Cincinnati Children's Hospital Medical Center, a large, 523-bed hospital located in Cincinnati. PATIENTS: Hospitalized children with laboratory-confirmed seasonal or H1N1infection. MEASUREMENTS: Study variables included demographic data (age, gender), clinical factors (weight, Pediatric Risk of Mortality III scores, presenting signs and symptoms, comorbid conditions), management (length of mechanical ventilation, other treatments, including high-frequency oscillatory ventilatory support, inhaled nitric oxide, or extracorporeal membrane oxygenation), and outcome (overall and pediatric intensive care unit length of stay and mortality). MAIN RESULTS: Overall, 312 children were hospitalized with H1N1 and 222 with seasonal influenza from the three previous seasons. Children with H1N1infection were significantly less likely to require pediatric intensive care unit care compared to children with seasonal influenza infection (14% vs. 24%, p = .02). Compared to children with seasonal influenza, children in the pediatric intensive care unit with H1N1 were older (median age in months 107 vs. 68, p = .05) and significantly more likely to have comorbid conditions (64% vs. 40%, p = .03), especially respiratory conditions. While there were no significant differences in severity of illness by Pediatric Risk of Mortality III scores or pediatric intensive care unit length of stay, children with H1N1 were significantly less likely to have acute respiratory failure (p = .04) or die compared to children with seasonal influenza infection (p = .03). CONCLUSIONS: In contrast to other studies, we found that critically ill children with H1N1 had a significantly lower morbidity and mortality compared to children with seasonal influenza.
Authors: Jessica Y Wong; Heath Kelly; Chung-Mei M Cheung; Eunice Y Shiu; Peng Wu; Michael Y Ni; Dennis K M Ip; Benjamin J Cowling Journal: Am J Epidemiol Date: 2015-07-18 Impact factor: 4.897
Authors: Mark W Hall; Susan M Geyer; Chao-Yu Guo; Angela Panoskaltsis-Mortari; Philippe Jouvet; Jill Ferdinands; David K Shay; Jyotsna Nateri; Kristin Greathouse; Ryan Sullivan; Tram Tran; Shannon Keisling; Adrienne G Randolph Journal: Crit Care Med Date: 2013-01 Impact factor: 7.598
Authors: Gulam Khandaker; Yvonne Zurynski; Greta Ridley; Jim Buttery; Helen Marshall; Peter C Richmond; Jenny Royle; Michael Gold; Tony Walls; Bruce Whitehead; Peter McIntyre; Nicholas Wood; Robert Booy; Elizabeth J Elliott Journal: Influenza Other Respir Viruses Date: 2014-09-27 Impact factor: 4.380
Authors: Bria M Coates; Kelly L Staricha; Nandini Ravindran; Clarissa M Koch; Yuan Cheng; Jennifer M Davis; Dale K Shumaker; Karen M Ridge Journal: Front Immunol Date: 2017-07-10 Impact factor: 7.561
Authors: Won Suk Choi; Ji Hyeon Baek; Yu Bin Seo; Sae Yoon Kee; Hye Won Jeong; Hee Young Lee; Byung Wook Eun; Eun Ju Choo; Jacob Lee; Young Keun Kim; Joon Young Song; Seong-Heon Wie; Jin Soo Lee; Hee Jin Cheong; Woo Joo Kim Journal: Korean J Intern Med Date: 2014-01-02 Impact factor: 2.884