Literature DB >> 21757748

Fatty acid induced remodeling within the human liver fatty acid-binding protein.

Ashwani Sharma1, Amit Sharma.   

Abstract

We crystallized human liver fatty acid-binding protein (LFABP) in apo, holo, and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry, and docking within LFABP support a heads-in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling, where the first palmitate ingress creates the atomic environment for placement of the second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFABP.

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Year:  2011        PMID： 21757748      PMCID： PMC3173104          DOI： 10.1074/jbc.M111.270165

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  30 in total

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