Literature DB >> 21757736

Functional in vitro analysis of the ERO1 protein and protein-disulfide isomerase pathway.

Kazutaka Araki1, Kazuhiro Nagata.   

Abstract

Oxidative protein folding in the endoplasmic reticulum is supported by efficient electron relays driven by enzymatic reactions centering on the ERO1-protein-disulfide isomerase (PDI) pathway. A controlled in vitro oxygen consumption assay was carried out to analyze the ERO1-PDI reaction. The results showed the pH-dependent oxidation of PDI by ERO1α. Among several possible disulfide bonds regulating ERO1α activity, Cys(94)-Cys(131) and Cys(99)-Cys(104) disulfide bonds are dominant regulators by excluding the involvement of the Cys(85)-Cys(391) disulfide in the regulation. The fine-tuned species specificity of the ERO1-PDI pathway was demonstrated by functional in vitro complementation assays using yeast and mammalian oxidoreductases. Finally, the results provide experimental evidence for the intramolecular electron transfer from the a domain to the a' domain within PDI during its oxidation by ERO1α.

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Year:  2011        PMID： 21757736      PMCID： PMC3173198          DOI： 10.1074/jbc.M111.227181

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  36 in total

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Review 2.  Quality control in the endoplasmic reticulum.

Authors:  Lars Ellgaard; Ari Helenius
Journal:  Nat Rev Mol Cell Biol       Date:  2003-03       Impact factor: 94.444

3.  Oxidative activity of yeast Ero1p on protein disulfide isomerase and related oxidoreductases of the endoplasmic reticulum.

Authors:  Elvira Vitu; Sunghwan Kim; Carolyn S Sevier; Omer Lutzky; Nimrod Heldman; Moran Bentzur; Tamar Unger; Meital Yona; Chris A Kaiser; Deborah Fass
Journal:  J Biol Chem       Date:  2010-03-26       Impact factor: 5.157

4.  Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI.

Authors:  Kenji Inaba; Shoji Masui; Hiroka Iida; Stefano Vavassori; Roberto Sitia; Mamoru Suzuki
Journal:  EMBO J       Date:  2010-09-10       Impact factor: 11.598

Review 5.  Proton-coupled electron flow in protein redox machines.

Authors:  Jillian L Dempsey; Jay R Winkler; Harry B Gray
Journal:  Chem Rev       Date:  2010-11-17       Impact factor: 60.622

6.  Molecular bases of cyclic and specific disulfide interchange between human ERO1alpha protein and protein-disulfide isomerase (PDI).

Authors:  Shoji Masui; Stefano Vavassori; Claudio Fagioli; Roberto Sitia; Kenji Inaba
Journal:  J Biol Chem       Date:  2011-03-11       Impact factor: 5.157

7.  Steps in reductive activation of the disulfide-generating enzyme Ero1p.

Authors:  Nimrod Heldman; Ohad Vonshak; Carolyn S Sevier; Elvira Vitu; Tevie Mehlman; Deborah Fass
Journal:  Protein Sci       Date:  2010-10       Impact factor: 6.725

8.  Plasticity of human protein disulfide isomerase: evidence for mobility around the X-linker region and its functional significance.

Authors:  Chao Wang; Sihong Chen; Xi Wang; Lei Wang; A Katrine Wallis; Robert B Freedman; Chih-chen Wang
Journal:  J Biol Chem       Date:  2010-06-01       Impact factor: 5.157

9.  The reduction potential of the active site disulfides of human protein disulfide isomerase limits oxidation of the enzyme by Ero1α.

Authors:  Joseph E Chambers; Timothy J Tavender; Ojore B V Oka; Stacey Warwood; David Knight; Neil J Bulleid
Journal:  J Biol Chem       Date:  2010-07-23       Impact factor: 5.157

10.  ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum.

Authors:  A Cabibbo; M Pagani; M Fabbri; M Rocchi; M R Farmery; N J Bulleid; R Sitia
Journal:  J Biol Chem       Date:  2000-02-18       Impact factor: 5.157
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  40 in total

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Journal:  Plant Physiol       Date:  2019-05-28       Impact factor: 8.340

2.  The b' domain of protein disulfide isomerase cooperates with the a and a' domains to functionally interact with platelets.

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Journal:  J Thromb Haemost       Date:  2019-02-03       Impact factor: 5.824

3.  Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α).

Authors:  Lihui Zhang; Yingbo Niu; Li Zhu; Jingqi Fang; Xi'e Wang; Lei Wang; Chih-chen Wang
Journal:  J Biol Chem       Date:  2014-09-25       Impact factor: 5.157

Review 4.  Interplay between redox and protein homeostasis.

Authors:  Diogo R Feleciano; Kristin Arnsburg; Janine Kirstein
Journal:  Worm       Date:  2016-03-30

5.  Hyperactivity of the Ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant response.

Authors:  Henning Gram Hansen; Jonas Damgård Schmidt; Cecilie Lützen Søltoft; Thomas Ramming; Henrik Marcus Geertz-Hansen; Brian Christensen; Esben Skipper Sørensen; Agnieszka Sierakowska Juncker; Christian Appenzeller-Herzog; Lars Ellgaard
Journal:  J Biol Chem       Date:  2012-10-01       Impact factor: 5.157

6.  Human ER Oxidoreductin-1α (Ero1α) Undergoes Dual Regulation through Complementary Redox Interactions with Protein-Disulfide Isomerase.

Authors:  Shingo Kanemura; Masaki Okumura; Katsuhide Yutani; Thomas Ramming; Takaaki Hikima; Christian Appenzeller-Herzog; Shuji Akiyama; Kenji Inaba
Journal:  J Biol Chem       Date:  2016-10-04       Impact factor: 5.157

7.  Anticancer effect of icaritin inhibits cell growth of colon cancer through reactive oxygen species, Bcl-2 and cyclin D1/E signaling.

Authors:  Chaofeng Li; Weichao Peng; Xin Song; Qian Wang; Wenyue Wang
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8.  An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1·cartilage-associated protein·cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro.

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9.  Structural insight into the dimerization of human protein disulfide isomerase.

Authors:  Sara Bastos-Aristizabal; Guennadi Kozlov; Kalle Gehring
Journal:  Protein Sci       Date:  2014-03-11       Impact factor: 6.725

10.  Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.

Authors:  Janine Kirstein; Daisuke Morito; Taichi Kakihana; Munechika Sugihara; Anita Minnen; Mark S Hipp; Carmen Nussbaum-Krammer; Prasad Kasturi; F Ulrich Hartl; Kazuhiro Nagata; Richard I Morimoto
Journal:  EMBO J       Date:  2015-07-29       Impact factor: 11.598
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