BACKGROUND AND PURPOSE: Cerebral microbleeds (CMB) are common in stroke survivors and the community-dwelling elderly. The clinical significance of CMB in the development of depression after a stroke is unknown. This study examined the association between poststroke depression (PSD) and CMB. METHODS: A cohort of 235 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the onset of the index stroke, a research assistant administered the locally validated 15-item Geriatric Depression Scale. PSD was defined as a Genetic Depression Scale score of ≥7. The presence and location of CMB were evaluated with MRI. RESULTS: In comparison with the non-PSD group, PSD patients were more likely to have lobar CMB (33.3% versus 19.9%; P=0.022). Lobar CMB remained an independent predictor of PSD in the multivariate analysis, with an odds ratio of 2.08 (P=0.032). CONCLUSIONS: The results suggest that lobar CMB may play a role in the development of PSD. The importance of CMB in the pathogenesis of depression in stroke survivors and the general elderly population warrants further investigation.
BACKGROUND AND PURPOSE: Cerebral microbleeds (CMB) are common in stroke survivors and the community-dwelling elderly. The clinical significance of CMB in the development of depression after a stroke is unknown. This study examined the association between poststroke depression (PSD) and CMB. METHODS: A cohort of 235 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the onset of the index stroke, a research assistant administered the locally validated 15-item Geriatric Depression Scale. PSD was defined as a Genetic Depression Scale score of ≥7. The presence and location of CMB were evaluated with MRI. RESULTS: In comparison with the non-PSD group, PSDpatients were more likely to have lobar CMB (33.3% versus 19.9%; P=0.022). Lobar CMB remained an independent predictor of PSD in the multivariate analysis, with an odds ratio of 2.08 (P=0.032). CONCLUSIONS: The results suggest that lobar CMB may play a role in the development of PSD. The importance of CMB in the pathogenesis of depression in stroke survivors and the general elderly population warrants further investigation.
Authors: S Choi-Kwon; K Han; S Choi; M Suh; Y-J Kim; H Song; K-H Cho; H-W Nah; S U Kwon; D-W Kang; J S Kim Journal: Neurology Date: 2012-03-28 Impact factor: 9.910
Authors: Liming Dong; Brisa N Sánchez; Lesli E Skolarus; Eric Stulberg; Lewis B Morgenstern; Lynda D Lisabeth Journal: Neurology Date: 2020-04-20 Impact factor: 9.910
Authors: Wai Kwong Tang; Dirk M Hermann; Yang Kun Chen; Hua Jun Liang; Xiang Xin Liu; Winnie Chui Wing Chu; Anil T Ahuja; Jill Abrigo; Vincent Mok; Gabor S Ungvari; Ka Sing Wong Journal: BMC Neurol Date: 2014-04-23 Impact factor: 2.474