Literature DB >> 2175718

The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase 1.

S Orgad1, N D Brewis, L Alphey, J M Axton, Y Dudai, P T Cohen.   

Abstract

cDNA coding for protein phosphatase 2A (PP2A) has been isolated from Drosophila head and eye imaginal disc libraries. Drosophila PP2A mRNA is expressed throughout development, but is most abundant in the early embryo. The cDNA hybridises to a single site on the left arm of the second chromosome at position 28D2-4. The deduced amino acid sequence (309 residues) of Drosophila PP2A shows 94% identity with either rabbit PP2A alpha or PP2A beta, indicating that PP2A may be the most conserved of all known enzymes.

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Year:  1990        PMID： 2175718     DOI： 10.1016/0014-5793(90)81435-q

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

1.  Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits.

Authors:  Adam M Silverstein; Christina A Barrow; Anthony J Davis; Marc C Mumby
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

Review 2.  Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.

Authors:  Parthasarathy Seshacharyulu; Poomy Pandey; Kaustubh Datta; Surinder K Batra
Journal:  Cancer Lett       Date:  2013-02-20       Impact factor: 8.679

3.  Active-site mutations impairing the catalytic function of the catalytic subunit of human protein phosphatase 2A permit baculovirus-mediated overexpression in insect cells.

Authors:  T Myles; K Schmidt; D R Evans; P Cron; B A Hemmings
Journal:  Biochem J       Date:  2001-07-01       Impact factor: 3.857

4.  Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans.

Authors:  Ken-ichi Ogura; Takako Okada; Shohei Mitani; Keiko Gengyo-Ando; David L Baillie; Yuji Kohara; Yoshio Goshima
Journal:  Development       Date:  2010-04-14       Impact factor: 6.868

5.  Identification and molecular cloning of two homologues of protein phosphatase X from Arabidopsis thaliana.

Authors:  E Pérez-Callejón; A Casamayor; G Pujol; E Clua; A Ferrer; J Ariño
Journal:  Plant Mol Biol       Date:  1993-12       Impact factor: 4.076

6.  A novel protein phosphatase 2A (PP2A) is involved in the transformation of human protozoan parasite Trypanosoma cruzi.

Authors:  Jorge González; Alberto Cornejo; Marcia R M Santos; Esteban M Cordero; Bessy Gutiérrez; Patricio Porcile; Renato A Mortara; Hernán Sagua; José Franco Da Silveira; Jorge E Araya
Journal:  Biochem J       Date:  2003-09-15       Impact factor: 3.857

7.  Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila.

Authors:  R E Mayer-Jaekel; S Baumgartner; G Bilbe; H Ohkura; D M Glover; B A Hemmings
Journal:  Mol Biol Cell       Date:  1992-03       Impact factor: 4.138

8.  Molecular characterization of a fourth isoform of the catalytic subunit of protein phosphatase 2A from Arabidopsis thaliana.

Authors:  A Casamayor; E Pérez-Callejón; G Pujol; J Ariño; A Ferrer
Journal:  Plant Mol Biol       Date:  1994-10       Impact factor: 4.076

9.  Inactivation of a single-2A phosphoprotein phosphatase is lethal in Neurospora crassa.

Authors:  E Yatzkan; O Yarden
Journal:  Curr Genet       Date:  1995-10       Impact factor: 3.886

10.  Protein phosphatases in higher plants: multiplicity of type 2A phosphatases in Arabidopsis thaliana.

Authors:  J Ariño; E Pérez-Callejón; N Cunillera; M Camps; F Posas; A Ferrer
Journal:  Plant Mol Biol       Date:  1993-02       Impact factor: 4.076
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