| Literature DB >> 2175717 |
V Dombrádi1, J M Axton, H M Barker, P T Cohen.
Abstract
A Drosophila gene encoding a protein phosphatase 1 (PP1) has been sequenced, and lethal mutations in this locus (87B) analysed. Two mutants (ck19e211 and ck19hs46), which disrupt mitosis, lack the 87B isoenzyme and express only approximately 20% of wild type PP1 activity. The promoter region of the gene is deleted in the ck19e211 mutant. A third mutant (ck19e078), which shows suppression of position effect variegation, but has little effect on mitosis, possesses approximately 35% of wild type PP1 activity. The results indicate that the PP1 87B isoenzyme is involved in regulation of chromosome condensation at interphase as well as mitosis.Entities:
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Year: 1990 PMID： 2175717 DOI： 10.1016/0014-5793(90)81434-p
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124