Literature DB >> 2175715

Functional expression of the rat heart I Na+ channel isoform. Demonstration of properties characteristic of native cardiac Na+ channels.

L L Cribbs1, J Satin, H A Fozzard, R B Rogart.   

Abstract

We describe the expression of functional Na+ channels in Xenopus oocytes injected with cRNA transcribed from the rat heart I cDNA clone. The expressed rat heart I Na+ currents show kinetic properties and resistance to tetrodotoxin and saxitoxin which are characteristic of native cardiac Na+ currents. The primary amino acid sequence of the rat heart I alpha-subunit is therefore sufficient for expression of tetrodotoxin resistance, and the rat heart I clone is likely to account for the tetrodotoxin-resistant phenotype of cardiac and denervated skeletal muscle.

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Year:  1990        PMID： 2175715     DOI： 10.1016/0014-5793(90)81470-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  22 in total

Review 1.  Tissue-specific expression of the voltage-sensitive sodium channel.

Authors:  G Mandel
Journal:  J Membr Biol       Date:  1992-02       Impact factor: 1.843

2.  Na+ currents are required for efficient excitation-contraction coupling in rabbit ventricular myocytes: a possible contribution of neuronal Na+ channels.

Authors:  Natalia S Torres; Robert Larbig; Alex Rock; Joshua I Goldhaber; John H B Bridge
Journal:  J Physiol       Date:  2010-11-01       Impact factor: 5.182

3.  Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

Authors:  Volker Haufe; Juan A Camacho; Robert Dumaine; Bernd Günther; Christian Bollensdorff; Gisela Segond von Banchet; Klaus Benndorf; Thomas Zimmer
Journal:  J Physiol       Date:  2005-03-03       Impact factor: 5.182

4.  Molecular determinants of beta 1 subunit-induced gating modulation in voltage-dependent Na+ channels.

Authors:  N Makita; P B Bennett; A L George
Journal:  J Neurosci       Date:  1996-11-15       Impact factor: 6.167

5.  A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.

Authors:  A Sunami; I W Glaaser; H A Fozzard
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

6.  The cloned cardiac Na channel alpha-subunit expressed in Xenopus oocytes show gating and blocking properties of native channels.

Authors:  J Satin; J W Kyle; M Chen; R B Rogart; H A Fozzard
Journal:  J Membr Biol       Date:  1992-10       Impact factor: 1.843

7.  Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells.

Authors:  M F Sheets; D A Hanck
Journal:  J Physiol       Date:  1992-08       Impact factor: 5.182

8.  Transfection of rat or mouse neurons by biolistics or electroporation.

Authors:  Sulayman D Dib-Hajj; Jin Sung Choi; Lawrence J Macala; Lynda Tyrrell; Joel A Black; Theodore R Cummins; Stephen G Waxman
Journal:  Nat Protoc       Date:  2009-07-09       Impact factor: 13.491

9.  Brain and heart sodium channel subtype mRNA expression in rat cerebral cortex.

Authors:  P J Yarowsky; B K Krueger; C E Olson; E C Clevinger; R D Koos
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

Review 10.  Na/Ca exchange and contraction of the heart.

Authors:  Michela Ottolia; Natalia Torres; John H B Bridge; Kenneth D Philipson; Joshua I Goldhaber
Journal:  J Mol Cell Cardiol       Date:  2013-06-12       Impact factor: 5.000
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