Jana Dragojevič1, Barbara Ostanek1, Simona Mencej-Bedrač1, Radko Komadina2, Janez Preželj3, Janja Marc4. 1. University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Aškerčeva cesta 7, SI 1000, Ljubljana, Slovenia. 2. General and Teaching Hospital Celje, Department of Traumatology, Oblakova ulica 5, SI 3000, Celje, Slovenia. 3. University Medical Centre Ljubljana, Department of Endocrinology, Diabetes and Metabolic Diseases, Zaloška cesta 7, SI 1000, Ljubljana, Slovenia. 4. University of Ljubljana, Faculty of Pharmacy, Department of Clinical Biochemistry, Aškerčeva cesta 7, SI 1000, Ljubljana, Slovenia. Electronic address: janja.marc@ffa.uni-lj.si.
Abstract
OBJECTIVES: Peroxisome proliferator-activated receptor γ (PPARγ), an essential transcription factor for adipogenesis, has been implicated in pathogenesis of osteoporosis. The association of three single nucleotide polymorphisms in the PPARG gene with hip fracture risk, bone mineral density (BMD) and biochemical markers of bone turnover was investigated in the elderly. DESIGN AND METHODS: Six hundred sixty-seven elderly Slovenians were genotyped for SNPs rs12497191, rs1801282 and rs3856806. BMD and biochemical markers of bone turnover were measured. Haplotypes ACC, AGT and GCC, defined by rs12497191, rs1801282 and rs3856806 were assigned. Influence of genotype on fracture risk was assessed in 72 non-traumatic hip fracture cases and 272 controls. RESULTS: The rs12497191 G allele alone or in haplotype was associated with lower risk of non-traumatic hip fracture and higher serum receptor activator of nuclear factor κB ligand. CONCLUSIONS: The rs12497191 genotype could contribute to the incidence of non-traumatic hip fractures in the elderly.
OBJECTIVES: Peroxisome proliferator-activated receptor γ (PPARγ), an essential transcription factor for adipogenesis, has been implicated in pathogenesis of osteoporosis. The association of three single nucleotide polymorphisms in the PPARG gene with hip fracture risk, bone mineral density (BMD) and biochemical markers of bone turnover was investigated in the elderly. DESIGN AND METHODS: Six hundred sixty-seven elderly Slovenians were genotyped for SNPs rs12497191, rs1801282 and rs3856806. BMD and biochemical markers of bone turnover were measured. Haplotypes ACC, AGT and GCC, defined by rs12497191, rs1801282 and rs3856806 were assigned. Influence of genotype on fracture risk was assessed in 72 non-traumatic hip fracture cases and 272 controls. RESULTS: The rs12497191 G allele alone or in haplotype was associated with lower risk of non-traumatic hip fracture and higher serum receptor activator of nuclear factor κB ligand. CONCLUSIONS: The rs12497191 genotype could contribute to the incidence of non-traumatic hip fractures in the elderly.
Authors: Moushira Zaki; Naglaa Hassan; Hala T El-Bassyouni; Sanaa Kamal; Walaa Basha; Osama Azmy; Khalda Amr Journal: Open Access Maced J Med Sci Date: 2017-06-13